FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076408766> ?p ?o ?g. }

• W2076408766 endingPage "1019" @default.
• W2076408766 startingPage "1013" @default.
• W2076408766 abstract "Proliferative vitreoretinopathy (PVR) is a common cause of intraoperative failure following retinal reattachment surgery and is mediated in part through the migration, de-differentiation and proliferation of retinal pigment epithelial (RPE) cells. Given the cytotoxic effects of curcumin on epithelial and endothelial cells, in this study, we assessed the effects of curcumin on human RPE (hRPE) cell proliferation. WST-1 analysis revealed that curcumin significantly inhibited primary hRPE cell proliferation in a dose- and time-dependent manner (P<0.001) with the greatest inhibition observed at the dose of 15 µg/ml curcumin. Flow cytometric analysis indicated that the cytotoxic effects of curcumin on hRPE cell proliferation were mediated by cell cycle arrest at the G0/G1 phase and the induction of apoptosis (both P<0.001), which was confirmed by ultrastructural analysis using transmission electron microscopy. Furthermore, western blot analysis revealed that curcumin induced p53 and p21(WAF1/CIP1) expression with a concomitant decrease in proliferating cell nuclear antigen protein levels (P<0.05). Curcumin effectively inhibited primary hRPE cell proliferation, which may be mediated by the p53 pathway. Further in vivo studies are required in order to fully explore the therapeutic potential of curcumin for PVR." @default.
• W2076408766 created "2016-06-24" @default.
• W2076408766 creator A5074157530 @default.
• W2076408766 creator A5074860235 @default.
• W2076408766 date "2014-07-23" @default.
• W2076408766 modified "2023-10-17" @default.
• W2076408766 title "Curcumin inhibits human retinal pigment epithelial cell proliferation" @default.
• W2076408766 cites W1520806449 @default.
• W2076408766 cites W1964114393 @default.
• W2076408766 cites W197462632 @default.
• W2076408766 cites W1979822085 @default.
• W2076408766 cites W1980080826 @default.
• W2076408766 cites W1980680365 @default.
• W2076408766 cites W1985820282 @default.
• W2076408766 cites W2011101407 @default.
• W2076408766 cites W2013706060 @default.
• W2076408766 cites W2018639198 @default.
• W2076408766 cites W2021055860 @default.
• W2076408766 cites W2037022487 @default.
• W2076408766 cites W2041883897 @default.
• W2076408766 cites W2048635128 @default.
• W2076408766 cites W2049300216 @default.
• W2076408766 cites W2052970766 @default.
• W2076408766 cites W2054085010 @default.
• W2076408766 cites W2055164201 @default.
• W2076408766 cites W2057049864 @default.
• W2076408766 cites W2057297075 @default.
• W2076408766 cites W2057487065 @default.
• W2076408766 cites W2059537653 @default.
• W2076408766 cites W2069656311 @default.
• W2076408766 cites W2071610165 @default.
• W2076408766 cites W2081308339 @default.
• W2076408766 cites W2083008063 @default.
• W2076408766 cites W2086536717 @default.
• W2076408766 cites W2087346415 @default.
• W2076408766 cites W2088943983 @default.
• W2076408766 cites W2093414762 @default.
• W2076408766 cites W2093718543 @default.
• W2076408766 cites W2094390105 @default.
• W2076408766 cites W2103441717 @default.
• W2076408766 cites W2108006472 @default.
• W2076408766 cites W2114914263 @default.
• W2076408766 cites W2127032008 @default.
• W2076408766 cites W2136295423 @default.
• W2076408766 cites W2155019246 @default.
• W2076408766 cites W2167713105 @default.
• W2076408766 cites W2169950408 @default.
• W2076408766 cites W2319186687 @default.
• W2076408766 cites W2333869006 @default.
• W2076408766 cites W96349842 @default.
• W2076408766 doi "https://doi.org/10.3892/ijmm.2014.1861" @default.
• W2076408766 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4152142" @default.
• W2076408766 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25070648" @default.
• W2076408766 hasPublicationYear "2014" @default.
• W2076408766 type Work @default.
• W2076408766 sameAs 2076408766 @default.
• W2076408766 citedByCount "16" @default.
• W2076408766 countsByYear W20764087662015 @default.
• W2076408766 countsByYear W20764087662016 @default.
• W2076408766 countsByYear W20764087662017 @default.
• W2076408766 countsByYear W20764087662018 @default.
• W2076408766 countsByYear W20764087662019 @default.
• W2076408766 countsByYear W20764087662021 @default.
• W2076408766 countsByYear W20764087662022 @default.
• W2076408766 crossrefType "journal-article" @default.
• W2076408766 hasAuthorship W2076408766A5074157530 @default.
• W2076408766 hasAuthorship W2076408766A5074860235 @default.
• W2076408766 hasBestOaLocation W20764087661 @default.
• W2076408766 hasConcept C105696609 @default.
• W2076408766 hasConcept C1491633281 @default.
• W2076408766 hasConcept C153911025 @default.
• W2076408766 hasConcept C185592680 @default.
• W2076408766 hasConcept C190283241 @default.
• W2076408766 hasConcept C2778024200 @default.
• W2076408766 hasConcept C2778250585 @default.
• W2076408766 hasConcept C2779059073 @default.
• W2076408766 hasConcept C2780428090 @default.
• W2076408766 hasConcept C2780827179 @default.
• W2076408766 hasConcept C29537977 @default.
• W2076408766 hasConcept C502942594 @default.
• W2076408766 hasConcept C553184892 @default.
• W2076408766 hasConcept C55493867 @default.
• W2076408766 hasConcept C62112901 @default.
• W2076408766 hasConcept C86803240 @default.
• W2076408766 hasConcept C95444343 @default.
• W2076408766 hasConcept C98274493 @default.
• W2076408766 hasConceptScore W2076408766C105696609 @default.
• W2076408766 hasConceptScore W2076408766C1491633281 @default.
• W2076408766 hasConceptScore W2076408766C153911025 @default.
• W2076408766 hasConceptScore W2076408766C185592680 @default.
• W2076408766 hasConceptScore W2076408766C190283241 @default.
• W2076408766 hasConceptScore W2076408766C2778024200 @default.
• W2076408766 hasConceptScore W2076408766C2778250585 @default.
• W2076408766 hasConceptScore W2076408766C2779059073 @default.
• W2076408766 hasConceptScore W2076408766C2780428090 @default.
• W2076408766 hasConceptScore W2076408766C2780827179 @default.
• W2076408766 hasConceptScore W2076408766C29537977 @default.
• W2076408766 hasConceptScore W2076408766C502942594 @default.

• next