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- W2076413516 endingPage "1212" @default.
- W2076413516 startingPage "1198" @default.
- W2076413516 abstract "Mechanical and thermal activation of ion channels is central to touch, thermosensation, and pain. The TRAAK/TREK K2P potassium channel subfamily produces background currents that alter neuronal excitability in response to pressure, temperature, signaling lipids, and anesthetics. How such diverse stimuli control channel function is unclear. Here we report structures of K2P4.1 (TRAAK) bearing C-type gate-activating mutations that reveal a tilting and straightening of the M4 inner transmembrane helix and a buckling of the M2 transmembrane helix. These conformational changes move M4 in a direction opposite to that in classical potassium channel activation mechanisms and open a passage lateral to the pore that faces the lipid bilayer inner leaflet. Together, our findings uncover a unique aspect of K2P modulation, indicate a means for how the K2P C-terminal cytoplasmic domain affects the C-type gate which lies ∼40Å away, and suggest how lipids and bilayer inner leaflet deformations may gate the channel." @default.
- W2076413516 created "2016-06-24" @default.
- W2076413516 creator A5005678327 @default.
- W2076413516 creator A5017627767 @default.
- W2076413516 creator A5040172058 @default.
- W2076413516 creator A5045437602 @default.
- W2076413516 creator A5079494512 @default.
- W2076413516 date "2014-12-01" @default.
- W2076413516 modified "2023-10-17" @default.
- W2076413516 title "Transmembrane Helix Straightening and Buckling Underlies Activation of Mechanosensitive and Thermosensitive K2P Channels" @default.
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