FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076413757> ?p ?o ?g. }

• W2076413757 endingPage "2444" @default.
• W2076413757 startingPage "2438" @default.
• W2076413757 abstract "In osteoblasts, retinoic acid (RA) modulates the synthesis of various proteins, including collagen. However, little is known about the effects of RA on the regulation of interstitial collagenase synthesis and collagen degradation. After treatment of primary osteoblast-enriched (Ob) cells from fetal rat calvariae with 100 nM all-trans-RA (tRA), collagenase mRNA levels, as determined by Northern blotting, did not change after 2 h, increased by 13- to 18-fold after 6 h, and remained elevated until 48 h. Exposure of Ob cells to 10 nM to 1 microM tRA, 13-cis-RA, and 9-cis-RA induced collagenase mRNA in a dose-dependent manner. Collagenase mRNA induction by RA was blocked by cycloheximide. RA increased the stability of collagenase mRNA in Ob cells, suggesting posttranscriptional regulation. Exposure of Ob cells to RA induced immunoreactive procollagenase in medium, as determined by enzyme-linked immunosorbent assay and Western blotting. RA action on collagen degradation was examined in [3H]proline-pulsed intact calvariae chased with and without tRA for 72 h. The release of [3H]hydroxyproline into culture medium was increased by 64% in the presence of 10 nM to 1 microM tRA. In conclusion, RA increases collagenase synthesis and collagen degradation in bone and is likely to play an important role in bone remodeling." @default.
• W2076413757 created "2016-06-24" @default.
• W2076413757 creator A5004430702 @default.
• W2076413757 creator A5011806639 @default.
• W2076413757 creator A5057066710 @default.
• W2076413757 creator A5089051861 @default.
• W2076413757 date "1994-06-01" @default.
• W2076413757 modified "2023-10-11" @default.
• W2076413757 title "Regulation of interstitial collagenase expression and collagen degradation by retinoic acid in bone cells." @default.
• W2076413757 cites W1452451700 @default.
• W2076413757 cites W1532387473 @default.
• W2076413757 cites W1577422435 @default.
• W2076413757 cites W1970096907 @default.
• W2076413757 cites W1972597519 @default.
• W2076413757 cites W1976018371 @default.
• W2076413757 cites W1979793843 @default.
• W2076413757 cites W1982831312 @default.
• W2076413757 cites W1984710885 @default.
• W2076413757 cites W1996706666 @default.
• W2076413757 cites W2010546282 @default.
• W2076413757 cites W2014669590 @default.
• W2076413757 cites W2022087872 @default.
• W2076413757 cites W2027468709 @default.
• W2076413757 cites W2030256390 @default.
• W2076413757 cites W2031912912 @default.
• W2076413757 cites W2037447928 @default.
• W2076413757 cites W2042818355 @default.
• W2076413757 cites W2053003267 @default.
• W2076413757 cites W2065930544 @default.
• W2076413757 cites W2066581502 @default.
• W2076413757 cites W2069309983 @default.
• W2076413757 cites W2069628761 @default.
• W2076413757 cites W2086722866 @default.
• W2076413757 cites W2087663008 @default.
• W2076413757 cites W2089938893 @default.
• W2076413757 cites W2091246953 @default.
• W2076413757 cites W2115269733 @default.
• W2076413757 cites W2122112217 @default.
• W2076413757 cites W2126931608 @default.
• W2076413757 cites W2134812217 @default.
• W2076413757 cites W2145349151 @default.
• W2076413757 cites W2153156904 @default.
• W2076413757 cites W2344080073 @default.
• W2076413757 cites W2734826710 @default.
• W2076413757 doi "https://doi.org/10.1210/endo.134.6.8194470" @default.
• W2076413757 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8194470" @default.
• W2076413757 hasPublicationYear "1994" @default.
• W2076413757 type Work @default.
• W2076413757 sameAs 2076413757 @default.
• W2076413757 citedByCount "47" @default.
• W2076413757 countsByYear W20764137572014 @default.
• W2076413757 countsByYear W20764137572016 @default.
• W2076413757 countsByYear W20764137572017 @default.
• W2076413757 countsByYear W20764137572019 @default.
• W2076413757 countsByYear W20764137572020 @default.
• W2076413757 countsByYear W20764137572022 @default.
• W2076413757 crossrefType "journal-article" @default.
• W2076413757 hasAuthorship W2076413757A5004430702 @default.
• W2076413757 hasAuthorship W2076413757A5011806639 @default.
• W2076413757 hasAuthorship W2076413757A5057066710 @default.
• W2076413757 hasAuthorship W2076413757A5089051861 @default.
• W2076413757 hasConcept C104317684 @default.
• W2076413757 hasConcept C105580179 @default.
• W2076413757 hasConcept C126322002 @default.
• W2076413757 hasConcept C134018914 @default.
• W2076413757 hasConcept C153911025 @default.
• W2076413757 hasConcept C177707886 @default.
• W2076413757 hasConcept C181199279 @default.
• W2076413757 hasConcept C185592680 @default.
• W2076413757 hasConcept C202751555 @default.
• W2076413757 hasConcept C2776747403 @default.
• W2076413757 hasConcept C2778128677 @default.
• W2076413757 hasConcept C2778260815 @default.
• W2076413757 hasConcept C2778394429 @default.
• W2076413757 hasConcept C2779797417 @default.
• W2076413757 hasConcept C2780644872 @default.
• W2076413757 hasConcept C2781121885 @default.
• W2076413757 hasConcept C3675279 @default.
• W2076413757 hasConcept C54355233 @default.
• W2076413757 hasConcept C55493867 @default.
• W2076413757 hasConcept C71924100 @default.
• W2076413757 hasConcept C81885089 @default.
• W2076413757 hasConcept C85265743 @default.
• W2076413757 hasConcept C86803240 @default.
• W2076413757 hasConceptScore W2076413757C104317684 @default.
• W2076413757 hasConceptScore W2076413757C105580179 @default.
• W2076413757 hasConceptScore W2076413757C126322002 @default.
• W2076413757 hasConceptScore W2076413757C134018914 @default.
• W2076413757 hasConceptScore W2076413757C153911025 @default.
• W2076413757 hasConceptScore W2076413757C177707886 @default.
• W2076413757 hasConceptScore W2076413757C181199279 @default.
• W2076413757 hasConceptScore W2076413757C185592680 @default.
• W2076413757 hasConceptScore W2076413757C202751555 @default.
• W2076413757 hasConceptScore W2076413757C2776747403 @default.
• W2076413757 hasConceptScore W2076413757C2778128677 @default.
• W2076413757 hasConceptScore W2076413757C2778260815 @default.
• W2076413757 hasConceptScore W2076413757C2778394429 @default.
• W2076413757 hasConceptScore W2076413757C2779797417 @default.

• next