FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076415130> ?p ?o ?g. }

• W2076415130 abstract "Recurrent HCV infection is universal in liver transplant recipients who are viremic pretransplant. The rate of histologic disease progression after transplantation is more rapid, and the risk of cirrhosis by 5 to 10 years is about 30%. Several donor, recipient, and viral factors have been associated with worse post-transplant outcomes in recipients with recurrent hepatitis C. Whether or not HCV-infected recipients of live donor grafts have worse out-comes compared with deceased donor graft recipients is controversial. To maximize the long-term survival of recipients with HCV infection, eradication of infection is the ultimate goal. Treatment of recurrent HCV after liver transplantation can be undertaken at several different time points: (1) prophylactically, at the time of transplantation; (2) pre-emptively, in the early post-transplant period; and (3) after established recurrent histologic disease is present. Prophylactic therapy for HCV infection has no established role at present, but studies are ongoing. Preemptive therapy using IFN and RBV has resulted in variable SVR rates (9%-43%) and is generally poorly tolerated, especially if the patient has advanced liver disease pretransplantation. Treatment of established recurrent HCV disease with combination PEGIFN and RBV is associated with a SVR in about 30% to 35% of patients overall but is limited by high rates of dose reduction or drug discontinuation. In conclusion, successful HCV eradication in the post-transplant setting is difficult with current treatment options, but it is possible. Determination of the optimal doses of antiviral drugs in transplant patients and improvements in drug tolerability may be important first steps in achieving enhanced response rates. There is a need for new drugs in this population that have greater efficacy and a better safety profile." @default.
• W2076415130 created "2016-06-24" @default.
• W2076415130 creator A5014267368 @default.
• W2076415130 creator A5019470247 @default.
• W2076415130 date "2006-03-01" @default.
• W2076415130 modified "2023-10-16" @default.
• W2076415130 title "Management of Recurrent Hepatitis C in Liver Transplant Recipients" @default.
• W2076415130 cites W142450307 @default.
• W2076415130 cites W1674991100 @default.
• W2076415130 cites W1963988343 @default.
• W2076415130 cites W1964496628 @default.
• W2076415130 cites W1966112709 @default.
• W2076415130 cites W1967392164 @default.
• W2076415130 cites W1969654131 @default.
• W2076415130 cites W1972673972 @default.
• W2076415130 cites W1974266777 @default.
• W2076415130 cites W1977185366 @default.
• W2076415130 cites W1979815055 @default.
• W2076415130 cites W1984028098 @default.
• W2076415130 cites W1985620786 @default.
• W2076415130 cites W1986026306 @default.
• W2076415130 cites W1988266921 @default.
• W2076415130 cites W1990751631 @default.
• W2076415130 cites W1992649802 @default.
• W2076415130 cites W1992904429 @default.
• W2076415130 cites W1993452820 @default.
• W2076415130 cites W1993628301 @default.
• W2076415130 cites W1995542582 @default.
• W2076415130 cites W1999996561 @default.
• W2076415130 cites W2003438137 @default.
• W2076415130 cites W2003849329 @default.
• W2076415130 cites W2006079477 @default.
• W2076415130 cites W2007791008 @default.
• W2076415130 cites W2009817284 @default.
• W2076415130 cites W2009833383 @default.
• W2076415130 cites W2011785130 @default.
• W2076415130 cites W2011892151 @default.
• W2076415130 cites W2012389069 @default.
• W2076415130 cites W2012808036 @default.
• W2076415130 cites W2014429466 @default.
• W2076415130 cites W2020021031 @default.
• W2076415130 cites W2024243893 @default.
• W2076415130 cites W2026720081 @default.
• W2076415130 cites W2026781470 @default.
• W2076415130 cites W2027001482 @default.
• W2076415130 cites W2029944598 @default.
• W2076415130 cites W2032016294 @default.
• W2076415130 cites W2034945905 @default.
• W2076415130 cites W2035508195 @default.
• W2076415130 cites W2052402745 @default.
• W2076415130 cites W2054721877 @default.
• W2076415130 cites W2055728067 @default.
• W2076415130 cites W2056347519 @default.
• W2076415130 cites W2057445015 @default.
• W2076415130 cites W2057465958 @default.
• W2076415130 cites W2059114505 @default.
• W2076415130 cites W2060057589 @default.
• W2076415130 cites W2062520706 @default.
• W2076415130 cites W2064428351 @default.
• W2076415130 cites W2065084710 @default.
• W2076415130 cites W2066166241 @default.
• W2076415130 cites W2074538265 @default.
• W2076415130 cites W2077221272 @default.
• W2076415130 cites W2078566988 @default.
• W2076415130 cites W2084112737 @default.
• W2076415130 cites W2089665384 @default.
• W2076415130 cites W2092380698 @default.
• W2076415130 cites W2093810804 @default.
• W2076415130 cites W2097430726 @default.
• W2076415130 cites W2102250111 @default.
• W2076415130 cites W2107893898 @default.
• W2076415130 cites W2123050268 @default.
• W2076415130 cites W2128390124 @default.
• W2076415130 cites W2128623775 @default.
• W2076415130 cites W2130301927 @default.
• W2076415130 cites W2134935617 @default.
• W2076415130 cites W2136890362 @default.
• W2076415130 cites W2141129600 @default.
• W2076415130 cites W2144169336 @default.
• W2076415130 cites W2150127865 @default.
• W2076415130 cites W2154690931 @default.
• W2076415130 cites W2155704117 @default.
• W2076415130 cites W2158008220 @default.
• W2076415130 cites W2160170863 @default.
• W2076415130 cites W2160866244 @default.
• W2076415130 cites W2164535490 @default.
• W2076415130 cites W2166971101 @default.
• W2076415130 cites W2318197279 @default.
• W2076415130 cites W2419252450 @default.
• W2076415130 cites W2422577652 @default.
• W2076415130 doi "https://doi.org/10.1016/j.idc.2006.01.011" @default.
• W2076415130 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16527654" @default.
• W2076415130 hasPublicationYear "2006" @default.
• W2076415130 type Work @default.
• W2076415130 sameAs 2076415130 @default.
• W2076415130 citedByCount "5" @default.
• W2076415130 countsByYear W20764151302014 @default.
• W2076415130 crossrefType "journal-article" @default.
• W2076415130 hasAuthorship W2076415130A5014267368 @default.
• W2076415130 hasAuthorship W2076415130A5019470247 @default.

• next