Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076417874> ?p ?o ?g. }
- W2076417874 endingPage "684" @default.
- W2076417874 startingPage "677" @default.
- W2076417874 abstract "1. The presence of arylhydrocarbon hydroxylase (cytochrome P-450 IA1 dependent), glutathione S-transferase, two distinct forms of epoxide hydrolases and UDP-glucuronosyltransferases was detected in H5-6 hepatoma cell homogenates using model substrates, selective inhibitors and specific antibodies. 2. The activity of arylhydrocarbon hydroxylase decreased strongly at the first days after plating and remained at a minimal value (1.5 pmol/min per mg) after 5 days of culture. 3. The hydratation of trans-stilbene oxide catalyzed by the soluble form of epoxide hydrolase was very low (11.0 pmol/min per mg), whereas the hepatoma cells contained appreciable amounts of the membrane-bound epoxide hydrolase and glutathione S-transferase measured with cis-stilbene oxide as substrate (maximal specific activity: 1.46 and 2.73 nmol/min per mg, respectively). 4. These cells also glucuronidated 1-naphthol efficiently (6 nmol/min per mg) and, at a lower extent, bilirubin (12 pmol/min per mg). 5. Addition of fenofibrate (70 microM) into the culture medium for 1-3 days failed to significantly stimulate the activity of cytosolic epoxide hydrolase. Only bilirubin glucuronidation increased 2-fold after 2 days of presence of the drug." @default.
- W2076417874 created "2016-06-24" @default.
- W2076417874 creator A5016776018 @default.
- W2076417874 creator A5068911282 @default.
- W2076417874 creator A5075309289 @default.
- W2076417874 creator A5089560972 @default.
- W2076417874 date "1991-01-01" @default.
- W2076417874 modified "2023-10-18" @default.
- W2076417874 title "Expression of arylhydrocarbon hydroxylase, epoxide hydrolases, glutathione S-transferase and UDP-glucuronosyltransferases in H5-6 hepatoma cells" @default.
- W2076417874 cites W1515756335 @default.
- W2076417874 cites W1566763721 @default.
- W2076417874 cites W1568156879 @default.
- W2076417874 cites W1775749144 @default.
- W2076417874 cites W1965070925 @default.
- W2076417874 cites W1965791965 @default.
- W2076417874 cites W1968807769 @default.
- W2076417874 cites W1974889801 @default.
- W2076417874 cites W1976997792 @default.
- W2076417874 cites W1977426698 @default.
- W2076417874 cites W1989494281 @default.
- W2076417874 cites W1993019601 @default.
- W2076417874 cites W1993548647 @default.
- W2076417874 cites W1997774836 @default.
- W2076417874 cites W2003663072 @default.
- W2076417874 cites W2011176046 @default.
- W2076417874 cites W2015373467 @default.
- W2076417874 cites W2022651698 @default.
- W2076417874 cites W2022720479 @default.
- W2076417874 cites W2026711299 @default.
- W2076417874 cites W2042218681 @default.
- W2076417874 cites W2055960964 @default.
- W2076417874 cites W2081990898 @default.
- W2076417874 cites W2084428007 @default.
- W2076417874 cites W2090746487 @default.
- W2076417874 cites W2093679589 @default.
- W2076417874 cites W2100837269 @default.
- W2076417874 cites W2111817213 @default.
- W2076417874 cites W2401391346 @default.
- W2076417874 doi "https://doi.org/10.1016/0306-3623(91)90077-j" @default.
- W2076417874 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1936901" @default.
- W2076417874 hasPublicationYear "1991" @default.
- W2076417874 type Work @default.
- W2076417874 sameAs 2076417874 @default.
- W2076417874 citedByCount "11" @default.
- W2076417874 countsByYear W20764178742012 @default.
- W2076417874 countsByYear W20764178742013 @default.
- W2076417874 countsByYear W20764178742014 @default.
- W2076417874 countsByYear W20764178742021 @default.
- W2076417874 crossrefType "journal-article" @default.
- W2076417874 hasAuthorship W2076417874A5016776018 @default.
- W2076417874 hasAuthorship W2076417874A5068911282 @default.
- W2076417874 hasAuthorship W2076417874A5075309289 @default.
- W2076417874 hasAuthorship W2076417874A5089560972 @default.
- W2076417874 hasConcept C101819947 @default.
- W2076417874 hasConcept C161790260 @default.
- W2076417874 hasConcept C181199279 @default.
- W2076417874 hasConcept C185592680 @default.
- W2076417874 hasConcept C2776376580 @default.
- W2076417874 hasConcept C2776671928 @default.
- W2076417874 hasConcept C2776907368 @default.
- W2076417874 hasConcept C2776920199 @default.
- W2076417874 hasConcept C2777477808 @default.
- W2076417874 hasConcept C2779907587 @default.
- W2076417874 hasConcept C538909803 @default.
- W2076417874 hasConcept C55493867 @default.
- W2076417874 hasConcept C87644729 @default.
- W2076417874 hasConceptScore W2076417874C101819947 @default.
- W2076417874 hasConceptScore W2076417874C161790260 @default.
- W2076417874 hasConceptScore W2076417874C181199279 @default.
- W2076417874 hasConceptScore W2076417874C185592680 @default.
- W2076417874 hasConceptScore W2076417874C2776376580 @default.
- W2076417874 hasConceptScore W2076417874C2776671928 @default.
- W2076417874 hasConceptScore W2076417874C2776907368 @default.
- W2076417874 hasConceptScore W2076417874C2776920199 @default.
- W2076417874 hasConceptScore W2076417874C2777477808 @default.
- W2076417874 hasConceptScore W2076417874C2779907587 @default.
- W2076417874 hasConceptScore W2076417874C538909803 @default.
- W2076417874 hasConceptScore W2076417874C55493867 @default.
- W2076417874 hasConceptScore W2076417874C87644729 @default.
- W2076417874 hasIssue "4" @default.
- W2076417874 hasLocation W20764178741 @default.
- W2076417874 hasLocation W20764178742 @default.
- W2076417874 hasOpenAccess W2076417874 @default.
- W2076417874 hasPrimaryLocation W20764178741 @default.
- W2076417874 hasRelatedWork W1848642262 @default.
- W2076417874 hasRelatedWork W2006302085 @default.
- W2076417874 hasRelatedWork W2050336168 @default.
- W2076417874 hasRelatedWork W2068382706 @default.
- W2076417874 hasRelatedWork W2075787698 @default.
- W2076417874 hasRelatedWork W2083367091 @default.
- W2076417874 hasRelatedWork W2089071106 @default.
- W2076417874 hasRelatedWork W2100783303 @default.
- W2076417874 hasRelatedWork W2149960979 @default.
- W2076417874 hasRelatedWork W2403430927 @default.
- W2076417874 hasVolume "22" @default.
- W2076417874 isParatext "false" @default.
- W2076417874 isRetracted "false" @default.
- W2076417874 magId "2076417874" @default.