FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076419093> ?p ?o ?g. }

• W2076419093 endingPage "e2807" @default.
• W2076419093 startingPage "e2807" @default.
• W2076419093 abstract "In an effort to enhance accuracy of diagnosis of Schistosoma haematobium, this study explores day-to-day variability and diagnostic performance of real-time PCR for detection and quantification of Schistosoma DNA compared to other diagnostic tools in an endemic area before and after treatment.Previously collected urine samples (N = 390) from 114 preselected proven parasitological and/or clinical S. haematobium positive Kenyan schoolchildren were analyzed by a Schistosoma internal transcribed spacer-based real-time PCR after 14 years of storage. Pre-treatment day-to-day fluctuations of PCR and microscopy over three consecutive days were measured for 24 children using intra-class correlation coefficient. A combined 'gold standard' (PCR and/or microscopy positive) was used to measure sensitivity and negative predictive value (NPV) of several diagnostic tools at baseline, two and 18 months post-treatment with praziquantel.All 24 repeatedly tested children were PCR-positive over three days with little daily variation in median Ct-values, while 83.3% were found to be egg-positive for S. haematobium at day 1 and 75.0% at day 2 and 3 pre-treatment, signifying daily fluctuations in microscopy diagnosis. Of all 114 preselected schoolchildren, repeated microscopic measurements were required to detect 96.5% versus 100% of positive pre-treatment cases by single PCR. At two months post-treatment, microscopy and PCR detected 22.8% versus 69.3% positive children, respectively. Based on the 'gold standard', PCR showed high sensitivity (>92%) as compared to >31% sensitivity for microscopy, both pre- and post-treatment.Detection and quantification of Schistosoma DNA in urine by real-time PCR was shown to be a powerful and specific diagnostic tool for detection of S. haematobium infections, with less day-to-day variation and higher sensitivity compared to microscopy. The superior performance of PCR before, and two and 18 months post-treatment provides a compelling argument for PCR as an accurate and reproducible tool for monitoring treatment efficacy." @default.
• W2076419093 created "2016-06-24" @default.
• W2076419093 creator A5010309280 @default.
• W2076419093 creator A5028385241 @default.
• W2076419093 creator A5032566952 @default.
• W2076419093 creator A5039675187 @default.
• W2076419093 creator A5059206108 @default.
• W2076419093 creator A5066447196 @default.
• W2076419093 creator A5090914260 @default.
• W2076419093 date "2014-04-17" @default.
• W2076419093 modified "2023-10-18" @default.
• W2076419093 title "Diagnostic Performance of Schistosoma Real-Time PCR in Urine Samples from Kenyan Children Infected with Schistosoma haematobium: Day-to-day Variation and Follow-up after Praziquantel Treatment" @default.
• W2076419093 cites W126028520 @default.
• W2076419093 cites W1859903208 @default.
• W2076419093 cites W1982946995 @default.
• W2076419093 cites W1986522398 @default.
• W2076419093 cites W1992344598 @default.
• W2076419093 cites W1997591745 @default.
• W2076419093 cites W2003495575 @default.
• W2076419093 cites W2005166293 @default.
• W2076419093 cites W2019972514 @default.
• W2076419093 cites W2025917796 @default.
• W2076419093 cites W2047247702 @default.
• W2076419093 cites W2051922719 @default.
• W2076419093 cites W2053169582 @default.
• W2076419093 cites W2055151500 @default.
• W2076419093 cites W2061087847 @default.
• W2076419093 cites W2061234942 @default.
• W2076419093 cites W2062086943 @default.
• W2076419093 cites W2064319894 @default.
• W2076419093 cites W2068225985 @default.
• W2076419093 cites W2077113463 @default.
• W2076419093 cites W2097953574 @default.
• W2076419093 cites W2126265637 @default.
• W2076419093 cites W2131233929 @default.
• W2076419093 cites W2132349697 @default.
• W2076419093 cites W2134098025 @default.
• W2076419093 cites W2136831466 @default.
• W2076419093 cites W2153533757 @default.
• W2076419093 cites W2156838404 @default.
• W2076419093 cites W2159354007 @default.
• W2076419093 cites W2160943186 @default.
• W2076419093 cites W2168451224 @default.
• W2076419093 cites W2186073358 @default.
• W2076419093 cites W2187087905 @default.
• W2076419093 cites W2296732095 @default.
• W2076419093 cites W2399610428 @default.
• W2076419093 cites W2417728381 @default.
• W2076419093 cites W4211120517 @default.
• W2076419093 doi "https://doi.org/10.1371/journal.pntd.0002807" @default.
• W2076419093 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3990496" @default.
• W2076419093 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24743389" @default.
• W2076419093 hasPublicationYear "2014" @default.
• W2076419093 type Work @default.
• W2076419093 sameAs 2076419093 @default.
• W2076419093 citedByCount "57" @default.
• W2076419093 countsByYear W20764190932014 @default.
• W2076419093 countsByYear W20764190932015 @default.
• W2076419093 countsByYear W20764190932016 @default.
• W2076419093 countsByYear W20764190932017 @default.
• W2076419093 countsByYear W20764190932018 @default.
• W2076419093 countsByYear W20764190932019 @default.
• W2076419093 countsByYear W20764190932020 @default.
• W2076419093 countsByYear W20764190932021 @default.
• W2076419093 countsByYear W20764190932022 @default.
• W2076419093 countsByYear W20764190932023 @default.
• W2076419093 crossrefType "journal-article" @default.
• W2076419093 hasAuthorship W2076419093A5010309280 @default.
• W2076419093 hasAuthorship W2076419093A5028385241 @default.
• W2076419093 hasAuthorship W2076419093A5032566952 @default.
• W2076419093 hasAuthorship W2076419093A5039675187 @default.
• W2076419093 hasAuthorship W2076419093A5059206108 @default.
• W2076419093 hasAuthorship W2076419093A5066447196 @default.
• W2076419093 hasAuthorship W2076419093A5090914260 @default.
• W2076419093 hasBestOaLocation W20764190931 @default.
• W2076419093 hasConcept C126322002 @default.
• W2076419093 hasConcept C165901193 @default.
• W2076419093 hasConcept C185592680 @default.
• W2076419093 hasConcept C187651312 @default.
• W2076419093 hasConcept C18903297 @default.
• W2076419093 hasConcept C203014093 @default.
• W2076419093 hasConcept C2776225656 @default.
• W2076419093 hasConcept C2776863245 @default.
• W2076419093 hasConcept C2777445151 @default.
• W2076419093 hasConcept C2778491710 @default.
• W2076419093 hasConcept C2779726973 @default.
• W2076419093 hasConcept C2779744950 @default.
• W2076419093 hasConcept C2780026642 @default.
• W2076419093 hasConcept C40993552 @default.
• W2076419093 hasConcept C43617362 @default.
• W2076419093 hasConcept C71924100 @default.
• W2076419093 hasConcept C86803240 @default.
• W2076419093 hasConcept C89838059 @default.
• W2076419093 hasConcept C90924648 @default.
• W2076419093 hasConceptScore W2076419093C126322002 @default.
• W2076419093 hasConceptScore W2076419093C165901193 @default.
• W2076419093 hasConceptScore W2076419093C185592680 @default.
• W2076419093 hasConceptScore W2076419093C187651312 @default.

• next