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- W2076428562 abstract "Insulin secretion is triggered by a rise in the intracellular Ca2+ concentration that results from the activation of voltage-gated Ca2+ channels in the β-cell plasma membrane. Multiple types of β-cell Ca2+ channel have been identified in both electrophysiological and molecular biological studies, but it appears that the L-type Ca2+ channel plays a dominant role in regulating Ca2+ influx. Activity of this channel is potentiated by protein kinases A and C and is inhibited by GTP-binding proteins, which may mediate the effects of potentiators and inhibitors of insulin secretion on Ca2+ influx, respectively. The mechanism by which elevation of intracellular Ca2+ leads to the release of insulin granules is not fully understood but appears to involve activation of Ca2+/calmodulin-dependent protein kinase. Phosphorylation by either protein kinase A or C, probably at different substrates, potentiates insulin secretion by acting at some late stage in the secretory process. There is also evidence that small GTP-binding proteins are involved in regulating exocytosis in β cells. The identification and characterisation of the proteins involved in exocytosis in β cells and clarification of the mechanism(s) of action of Ca2+ is clearly an important goal for the future. © 1994 Wiley-Liss, Inc." @default.
- W2076428562 created "2016-06-24" @default.
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- W2076428562 date "1994-01-01" @default.
- W2076428562 modified "2023-10-02" @default.
- W2076428562 title "Stimulus-secretion coupling in pancreatic β cells" @default.
- W2076428562 cites W139148589 @default.
- W2076428562 cites W150258088 @default.
- W2076428562 cites W1516614444 @default.
- W2076428562 cites W1530460707 @default.
- W2076428562 cites W1531564543 @default.
- W2076428562 cites W1549576466 @default.
- W2076428562 cites W1574259249 @default.
- W2076428562 cites W1585798997 @default.
- W2076428562 cites W1587263644 @default.
- W2076428562 cites W1595907824 @default.
- W2076428562 cites W1602447595 @default.
- W2076428562 cites W1624592313 @default.
- W2076428562 cites W1758028381 @default.
- W2076428562 cites W181566666 @default.
- W2076428562 cites W1964563218 @default.
- W2076428562 cites W1965005201 @default.
- W2076428562 cites W1966997010 @default.
- W2076428562 cites W1968498807 @default.
- W2076428562 cites W196960734 @default.
- W2076428562 cites W1970249565 @default.
- W2076428562 cites W1971881171 @default.
- W2076428562 cites W1976851725 @default.
- W2076428562 cites W1977738244 @default.
- W2076428562 cites W1981547910 @default.
- W2076428562 cites W1983488208 @default.
- W2076428562 cites W1984540625 @default.
- W2076428562 cites W1984698199 @default.
- W2076428562 cites W1986563753 @default.
- W2076428562 cites W1992045485 @default.
- W2076428562 cites W1993283491 @default.
- W2076428562 cites W1994964354 @default.
- W2076428562 cites W1996514721 @default.
- W2076428562 cites W1999645386 @default.
- W2076428562 cites W2000977514 @default.
- W2076428562 cites W2004788546 @default.
- W2076428562 cites W2005166745 @default.
- W2076428562 cites W2005870046 @default.
- W2076428562 cites W2006510348 @default.
- W2076428562 cites W2006700291 @default.
- W2076428562 cites W2007082672 @default.
- W2076428562 cites W2013907969 @default.
- W2076428562 cites W2016813596 @default.
- W2076428562 cites W2018570709 @default.
- W2076428562 cites W2021925516 @default.
- W2076428562 cites W2023662309 @default.
- W2076428562 cites W2025972769 @default.
- W2076428562 cites W2028946878 @default.
- W2076428562 cites W2031580961 @default.
- W2076428562 cites W2037812888 @default.
- W2076428562 cites W2040015414 @default.
- W2076428562 cites W2044187333 @default.
- W2076428562 cites W2044252404 @default.
- W2076428562 cites W2044844426 @default.
- W2076428562 cites W2048065530 @default.
- W2076428562 cites W2057736378 @default.
- W2076428562 cites W2060705547 @default.
- W2076428562 cites W2061056399 @default.
- W2076428562 cites W2062100108 @default.
- W2076428562 cites W2064140983 @default.
- W2076428562 cites W2064916160 @default.
- W2076428562 cites W2065011201 @default.
- W2076428562 cites W2065959431 @default.
- W2076428562 cites W2077178297 @default.
- W2076428562 cites W2080195840 @default.
- W2076428562 cites W2080395264 @default.
- W2076428562 cites W2088232866 @default.
- W2076428562 cites W2090133526 @default.
- W2076428562 cites W2133768969 @default.
- W2076428562 cites W2140080662 @default.
- W2076428562 cites W2140962689 @default.
- W2076428562 cites W2140984728 @default.
- W2076428562 cites W2152969853 @default.
- W2076428562 cites W2164416985 @default.
- W2076428562 cites W2203328182 @default.
- W2076428562 cites W2218148748 @default.
- W2076428562 cites W2235535800 @default.
- W2076428562 cites W2258678574 @default.
- W2076428562 cites W2312574617 @default.
- W2076428562 cites W2328734100 @default.
- W2076428562 cites W2394892085 @default.
- W2076428562 cites W2406479238 @default.
- W2076428562 cites W2412703865 @default.
- W2076428562 cites W2415444890 @default.
- W2076428562 cites W2486690109 @default.
- W2076428562 cites W57578819 @default.
- W2076428562 cites W58251843 @default.
- W2076428562 doi "https://doi.org/10.1002/jcb.240550007" @default.