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• W2076440801 abstract "Andrastins (andrastin A-D), produced by several Penicillium species, exhibit inhibitory activity against ras farnesyltransferase, suggesting that these compounds could be promising leads for antitumor agents. Although the genome sequence of Penicillium chrysogenum, an andrastin-producing species, is available, the genetic and molecular bases for the biosynthesis of andrastins have not been elucidated. Here we report the identification and characterization of the gene cluster for andrastin biosynthesis. We reconstituted the biosynthetic pathway in Aspergillus oryzae, a fungal expression host, by the co-expression of five genes, including that of a terpene cyclase, and of four genes encoding the tailoring enzymes, required for the generation of andrastins. Remarkably, we successfully obtained andrastin A, the most complex andrastin molecule, as the metabolite of nine gene products, thus confirming the potential of the fungal expression system to synthesize useful natural products." @default.
• W2076440801 created "2016-06-24" @default.
• W2076440801 creator A5001494964 @default.
• W2076440801 creator A5004078670 @default.
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• W2076440801 date "2013-09-01" @default.
• W2076440801 modified "2023-10-16" @default.
• W2076440801 title "Reconstituted biosynthesis of fungal meroterpenoid andrastin A" @default.
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• W2076440801 doi "https://doi.org/10.1016/j.tet.2013.07.029" @default.
• W2076440801 hasPublicationYear "2013" @default.
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