Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076442008> ?p ?o ?g. }
- W2076442008 endingPage "1005" @default.
- W2076442008 startingPage "1000" @default.
- W2076442008 abstract "Cystic fibrosis (CF) lung disease is primarily a disease of the small airways. We hypothesized that even in patients with normal lung function, a reduced surfactant function would be present and favor small airway obstruction. Bronchoalveolar lavages from 76 patients with CF (5-31 years, median 11) with well-conserved lung function (FEV1 94% predicted, range 78-121) and from 10 healthy control subjects were investigated. The deviation of the biophysical surfactant performance from normal, assessed in a bubble surfactometer, was small; however, the ability of the surfactant to maintain the patency of a narrow airway (% open) was significantly reduced. Surfactant protein (SP)-C level was increased, SP-B and SP-D were unchanged, whereas SP-A was decreased. Among the patients with CF, neutrophilic inflammation was modestly related to a poorer surfactant activity, but not to lung function. SP-D was reduced in proportion to the degree of inflammation and in the presence of bacteria. These findings in a large cohort of patients with CF with normal lung function show that the endobronchial airway inflammation is linked to early perturbations of the biophysical properties and immunologic components of pulmonary surfactant and opens fields for novel therapeutic interventions." @default.
- W2076442008 created "2016-06-24" @default.
- W2076442008 creator A5015555168 @default.
- W2076442008 creator A5017024281 @default.
- W2076442008 creator A5035961141 @default.
- W2076442008 creator A5051814444 @default.
- W2076442008 creator A5065547785 @default.
- W2076442008 creator A5071091256 @default.
- W2076442008 creator A5079784442 @default.
- W2076442008 date "2004-11-01" @default.
- W2076442008 modified "2023-10-17" @default.
- W2076442008 title "Pulmonary Surfactant, Lung Function, and Endobronchial Inflammation in Cystic Fibrosis" @default.
- W2076442008 cites W1538406393 @default.
- W2076442008 cites W1967576499 @default.
- W2076442008 cites W1969921713 @default.
- W2076442008 cites W1980017808 @default.
- W2076442008 cites W1980242834 @default.
- W2076442008 cites W1984783369 @default.
- W2076442008 cites W2002641136 @default.
- W2076442008 cites W2020012047 @default.
- W2076442008 cites W2023449363 @default.
- W2076442008 cites W2040152985 @default.
- W2076442008 cites W2044279773 @default.
- W2076442008 cites W2055857822 @default.
- W2076442008 cites W2057061730 @default.
- W2076442008 cites W2057426111 @default.
- W2076442008 cites W2063995227 @default.
- W2076442008 cites W2067127493 @default.
- W2076442008 cites W2067246285 @default.
- W2076442008 cites W2070364452 @default.
- W2076442008 cites W2093023007 @default.
- W2076442008 cites W2102842144 @default.
- W2076442008 cites W2107884278 @default.
- W2076442008 cites W2108935488 @default.
- W2076442008 cites W2121403538 @default.
- W2076442008 cites W2124366530 @default.
- W2076442008 cites W2127856096 @default.
- W2076442008 cites W2130936338 @default.
- W2076442008 cites W2144102711 @default.
- W2076442008 cites W2145726881 @default.
- W2076442008 cites W2149906284 @default.
- W2076442008 cites W2155768189 @default.
- W2076442008 cites W2158898740 @default.
- W2076442008 cites W2160856572 @default.
- W2076442008 cites W2164858108 @default.
- W2076442008 cites W2165893661 @default.
- W2076442008 cites W2171864472 @default.
- W2076442008 cites W2227095361 @default.
- W2076442008 cites W4241088435 @default.
- W2076442008 cites W4254475114 @default.
- W2076442008 cites W4255436411 @default.
- W2076442008 doi "https://doi.org/10.1164/rccm.200405-575oc" @default.
- W2076442008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15271694" @default.
- W2076442008 hasPublicationYear "2004" @default.
- W2076442008 type Work @default.
- W2076442008 sameAs 2076442008 @default.
- W2076442008 citedByCount "73" @default.
- W2076442008 countsByYear W20764420082012 @default.
- W2076442008 countsByYear W20764420082013 @default.
- W2076442008 countsByYear W20764420082014 @default.
- W2076442008 countsByYear W20764420082015 @default.
- W2076442008 countsByYear W20764420082016 @default.
- W2076442008 countsByYear W20764420082017 @default.
- W2076442008 countsByYear W20764420082018 @default.
- W2076442008 countsByYear W20764420082019 @default.
- W2076442008 countsByYear W20764420082021 @default.
- W2076442008 countsByYear W20764420082022 @default.
- W2076442008 countsByYear W20764420082023 @default.
- W2076442008 crossrefType "journal-article" @default.
- W2076442008 hasAuthorship W2076442008A5015555168 @default.
- W2076442008 hasAuthorship W2076442008A5017024281 @default.
- W2076442008 hasAuthorship W2076442008A5035961141 @default.
- W2076442008 hasAuthorship W2076442008A5051814444 @default.
- W2076442008 hasAuthorship W2076442008A5065547785 @default.
- W2076442008 hasAuthorship W2076442008A5071091256 @default.
- W2076442008 hasAuthorship W2076442008A5079784442 @default.
- W2076442008 hasBestOaLocation W20764420082 @default.
- W2076442008 hasConcept C105922876 @default.
- W2076442008 hasConcept C126322002 @default.
- W2076442008 hasConcept C141071460 @default.
- W2076442008 hasConcept C142724271 @default.
- W2076442008 hasConcept C194108754 @default.
- W2076442008 hasConcept C203014093 @default.
- W2076442008 hasConcept C2776178081 @default.
- W2076442008 hasConcept C2776914184 @default.
- W2076442008 hasConcept C2776938444 @default.
- W2076442008 hasConcept C2777714996 @default.
- W2076442008 hasConcept C2777961210 @default.
- W2076442008 hasConcept C3018587741 @default.
- W2076442008 hasConcept C55493867 @default.
- W2076442008 hasConcept C58226133 @default.
- W2076442008 hasConcept C71924100 @default.
- W2076442008 hasConcept C75603125 @default.
- W2076442008 hasConcept C86803240 @default.
- W2076442008 hasConcept C90924648 @default.
- W2076442008 hasConceptScore W2076442008C105922876 @default.
- W2076442008 hasConceptScore W2076442008C126322002 @default.
- W2076442008 hasConceptScore W2076442008C141071460 @default.