Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076442990> ?p ?o ?g. }
- W2076442990 endingPage "217" @default.
- W2076442990 startingPage "208" @default.
- W2076442990 abstract "Traditionally a pursuit of large pharmaceutical companies, high-throughput screening assays are becoming increasingly common within academic and government laboratories. This shift has been instrumental in enabling projects that have not been commercially viable, such as chemical probe discovery and screening against high-risk targets. Once an assay has been prepared and validated, it must be fed with screening compounds. Crafting a successful collection of small molecules for screening poses a significant challenge. An optimized collection will minimize false positives while maximizing hit rates of compounds that are amenable to lead generation and optimization. Without due consideration of the relevant protein targets and the downstream screening assays, compound filtering and selection can fail to explore the great extent of chemical diversity and eschew valuable novelty. Herein, we discuss the different factors to be considered and methods that may be employed when assembling a structurally diverse compound collection for screening. Rational methods for selecting diverse chemical libraries are essential for their effective use in high-throughput screens." @default.
- W2076442990 created "2016-06-24" @default.
- W2076442990 creator A5000950100 @default.
- W2076442990 creator A5075346091 @default.
- W2076442990 creator A5086913774 @default.
- W2076442990 date "2011-02-15" @default.
- W2076442990 modified "2023-09-24" @default.
- W2076442990 title "Rational Methods for the Selection of Diverse Screening Compounds" @default.
- W2076442990 cites W1489601464 @default.
- W2076442990 cites W1518389484 @default.
- W2076442990 cites W155109449 @default.
- W2076442990 cites W1574994167 @default.
- W2076442990 cites W1640748652 @default.
- W2076442990 cites W1966875239 @default.
- W2076442990 cites W1969921890 @default.
- W2076442990 cites W1970329726 @default.
- W2076442990 cites W1974240614 @default.
- W2076442990 cites W1975147762 @default.
- W2076442990 cites W1978009405 @default.
- W2076442990 cites W1979142801 @default.
- W2076442990 cites W1981172305 @default.
- W2076442990 cites W1981214699 @default.
- W2076442990 cites W1988909822 @default.
- W2076442990 cites W1990451437 @default.
- W2076442990 cites W2000541041 @default.
- W2076442990 cites W2002009218 @default.
- W2076442990 cites W2003708609 @default.
- W2076442990 cites W2003932708 @default.
- W2076442990 cites W2006641674 @default.
- W2076442990 cites W2007066406 @default.
- W2076442990 cites W2008525757 @default.
- W2076442990 cites W2009588798 @default.
- W2076442990 cites W2010630721 @default.
- W2076442990 cites W2011505858 @default.
- W2076442990 cites W2016836376 @default.
- W2076442990 cites W2017254234 @default.
- W2076442990 cites W2017380317 @default.
- W2076442990 cites W2017946427 @default.
- W2076442990 cites W2018359045 @default.
- W2076442990 cites W2022265395 @default.
- W2076442990 cites W2024680115 @default.
- W2076442990 cites W2027065525 @default.
- W2076442990 cites W2027816595 @default.
- W2076442990 cites W2029666115 @default.
- W2076442990 cites W2032353075 @default.
- W2076442990 cites W2036922942 @default.
- W2076442990 cites W2039384791 @default.
- W2076442990 cites W2039478311 @default.
- W2076442990 cites W2039992584 @default.
- W2076442990 cites W2040066247 @default.
- W2076442990 cites W2041774091 @default.
- W2076442990 cites W2042338355 @default.
- W2076442990 cites W2042721486 @default.
- W2076442990 cites W2043509228 @default.
- W2076442990 cites W2046258407 @default.
- W2076442990 cites W2046564413 @default.
- W2076442990 cites W2047710091 @default.
- W2076442990 cites W2052723761 @default.
- W2076442990 cites W2052907531 @default.
- W2076442990 cites W2058735345 @default.
- W2076442990 cites W2061789405 @default.
- W2076442990 cites W2062458432 @default.
- W2076442990 cites W2064815566 @default.
- W2076442990 cites W2065915163 @default.
- W2076442990 cites W2074274985 @default.
- W2076442990 cites W2074940029 @default.
- W2076442990 cites W2075043416 @default.
- W2076442990 cites W2082069106 @default.
- W2076442990 cites W2083441741 @default.
- W2076442990 cites W2086729168 @default.
- W2076442990 cites W2088536322 @default.
- W2076442990 cites W2089966673 @default.
- W2076442990 cites W2096729078 @default.
- W2076442990 cites W2097233276 @default.
- W2076442990 cites W2109259347 @default.
- W2076442990 cites W2109387943 @default.
- W2076442990 cites W2111115182 @default.
- W2076442990 cites W2113364934 @default.
- W2076442990 cites W2116594309 @default.
- W2076442990 cites W2124072633 @default.
- W2076442990 cites W2126662293 @default.
- W2076442990 cites W2130839195 @default.
- W2076442990 cites W2131730587 @default.
- W2076442990 cites W2141474275 @default.
- W2076442990 cites W2142309820 @default.
- W2076442990 cites W2143809707 @default.
- W2076442990 cites W2152179597 @default.
- W2076442990 cites W2154183412 @default.
- W2076442990 cites W2156077095 @default.
- W2076442990 cites W2157619122 @default.
- W2076442990 cites W2159266419 @default.
- W2076442990 cites W2166594615 @default.
- W2076442990 cites W2169303530 @default.
- W2076442990 cites W2170146596 @default.
- W2076442990 cites W2170515228 @default.
- W2076442990 cites W2171955717 @default.
- W2076442990 cites W2176516200 @default.
- W2076442990 cites W2205755822 @default.