FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076444039> ?p ?o ?g. }

• W2076444039 endingPage "220" @default.
• W2076444039 startingPage "215" @default.
• W2076444039 abstract "Purpose of review The purpose of this study is to discuss the involvement of bone and morphogenetic proteins (BMPs) in the control of muscle mass. Recent findings The transforming growth factor-beta (TGFβ) superfamily comprises a large number of secreted proteins that regulate a variety of fundamental biological processes. Sequence similarities define two ligand subfamilies: the TGFβ/Activin subfamily and the BMP subfamily. Within the members of TGFβ subfamily, myostatin emerged as the most critical ligand that affects muscle size and function. Indeed, mutations that inactivate Myostatin lead to important muscle growth in animals and humans. However, recent findings have increased the complexity of the TGFβ superfamily. Indeed, two independent groups have shown that BMP pathway, acting through Smad1/5/8, is the fundamental hypertrophic signal and dominates Myostatin signalling. Moreover, BMP-Smad1/5/8 negatively regulates a novel ubiquitin ligase, named MUSA1 that is required for muscle loss. This article reviews the rapid progress made in the last year regarding the signalling downstream TGFβ superfamily and its involvement in the homeostasis of adult muscle fibres. Summary The recent insights gained into the interplay of TGFβ and BMP signalling in muscle have challenged our pre-existing ideas of how the adult skeletal muscle phenotype is regulated in health and disease." @default.
• W2076444039 created "2016-06-24" @default.
• W2076444039 creator A5062671029 @default.
• W2076444039 creator A5078909013 @default.
• W2076444039 date "2015-05-01" @default.
• W2076444039 modified "2023-09-26" @default.
• W2076444039 title "Bone and morphogenetic protein signalling and muscle mass" @default.
• W2076444039 cites W1966910567 @default.
• W2076444039 cites W1977116914 @default.
• W2076444039 cites W1984706329 @default.
• W2076444039 cites W1990318883 @default.
• W2076444039 cites W1993476327 @default.
• W2076444039 cites W1997014674 @default.
• W2076444039 cites W2009641783 @default.
• W2076444039 cites W2012836529 @default.
• W2076444039 cites W2020007904 @default.
• W2076444039 cites W2031936495 @default.
• W2076444039 cites W2044120589 @default.
• W2076444039 cites W2054594032 @default.
• W2076444039 cites W2054800877 @default.
• W2076444039 cites W2056331158 @default.
• W2076444039 cites W2067488166 @default.
• W2076444039 cites W2067796970 @default.
• W2076444039 cites W2073104176 @default.
• W2076444039 cites W2087293183 @default.
• W2076444039 cites W2102107385 @default.
• W2076444039 cites W2105555459 @default.
• W2076444039 cites W2105597626 @default.
• W2076444039 cites W2113679184 @default.
• W2076444039 cites W2132489058 @default.
• W2076444039 cites W2139128868 @default.
• W2076444039 cites W2148527632 @default.
• W2076444039 cites W2151283204 @default.
• W2076444039 cites W2154241781 @default.
• W2076444039 cites W2157644555 @default.
• W2076444039 cites W2166429987 @default.
• W2076444039 cites W2166485013 @default.
• W2076444039 cites W2167512318 @default.
• W2076444039 cites W2197107516 @default.
• W2076444039 cites W4251897205 @default.
• W2076444039 doi "https://doi.org/10.1097/mco.0000000000000172" @default.
• W2076444039 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25807347" @default.
• W2076444039 hasPublicationYear "2015" @default.
• W2076444039 type Work @default.
• W2076444039 sameAs 2076444039 @default.
• W2076444039 citedByCount "16" @default.
• W2076444039 countsByYear W20764440392015 @default.
• W2076444039 countsByYear W20764440392016 @default.
• W2076444039 countsByYear W20764440392017 @default.
• W2076444039 countsByYear W20764440392018 @default.
• W2076444039 countsByYear W20764440392019 @default.
• W2076444039 countsByYear W20764440392020 @default.
• W2076444039 countsByYear W20764440392021 @default.
• W2076444039 countsByYear W20764440392022 @default.
• W2076444039 countsByYear W20764440392023 @default.
• W2076444039 crossrefType "journal-article" @default.
• W2076444039 hasAuthorship W2076444039A5062671029 @default.
• W2076444039 hasAuthorship W2076444039A5078909013 @default.
• W2076444039 hasConcept C104317684 @default.
• W2076444039 hasConcept C118131993 @default.
• W2076444039 hasConcept C127716648 @default.
• W2076444039 hasConcept C134018914 @default.
• W2076444039 hasConcept C134459356 @default.
• W2076444039 hasConcept C146539212 @default.
• W2076444039 hasConcept C202751555 @default.
• W2076444039 hasConcept C25602115 @default.
• W2076444039 hasConcept C2777488582 @default.
• W2076444039 hasConcept C2778229498 @default.
• W2076444039 hasConcept C2778649528 @default.
• W2076444039 hasConcept C2779959927 @default.
• W2076444039 hasConcept C2781080636 @default.
• W2076444039 hasConcept C30352789 @default.
• W2076444039 hasConcept C31507581 @default.
• W2076444039 hasConcept C50929876 @default.
• W2076444039 hasConcept C54355233 @default.
• W2076444039 hasConcept C86803240 @default.
• W2076444039 hasConcept C95444343 @default.
• W2076444039 hasConceptScore W2076444039C104317684 @default.
• W2076444039 hasConceptScore W2076444039C118131993 @default.
• W2076444039 hasConceptScore W2076444039C127716648 @default.
• W2076444039 hasConceptScore W2076444039C134018914 @default.
• W2076444039 hasConceptScore W2076444039C134459356 @default.
• W2076444039 hasConceptScore W2076444039C146539212 @default.
• W2076444039 hasConceptScore W2076444039C202751555 @default.
• W2076444039 hasConceptScore W2076444039C25602115 @default.
• W2076444039 hasConceptScore W2076444039C2777488582 @default.
• W2076444039 hasConceptScore W2076444039C2778229498 @default.
• W2076444039 hasConceptScore W2076444039C2778649528 @default.
• W2076444039 hasConceptScore W2076444039C2779959927 @default.
• W2076444039 hasConceptScore W2076444039C2781080636 @default.
• W2076444039 hasConceptScore W2076444039C30352789 @default.
• W2076444039 hasConceptScore W2076444039C31507581 @default.
• W2076444039 hasConceptScore W2076444039C50929876 @default.
• W2076444039 hasConceptScore W2076444039C54355233 @default.
• W2076444039 hasConceptScore W2076444039C86803240 @default.
• W2076444039 hasConceptScore W2076444039C95444343 @default.
• W2076444039 hasIssue "3" @default.
• W2076444039 hasLocation W20764440391 @default.

• next