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- W2076445856 abstract "Changes in troponin C (TnC) conformation upon Ca(2+) binding forms the basis for regulatory and structural functions of TnC molecules. In the present study, Ca(2+)-induced conformational changes in TnC were observed by mechanical measurements. TnC films were prepared by drying or electrospraying TnC solutions, cross-linked with glutaraldehyde, and isometric tension and stiffness measured as a function of pCa. An increase in Ca(2+) from a pCa of 9 to 4 induced large-scale mechanical changes in the TnC films causing several percent shrinkage of the unloaded films. This shrinkage could be partially assigned to Ca(2+) binding to the Ca(2+)/Mg(2+) sites of TnC." @default.
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- W2076445856 date "2002-07-01" @default.
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- W2076445856 title "Mechano-chemical effects of Ca<sup>2+</sup>in cross-linked troponin-C films" @default.
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- W2076445856 doi "https://doi.org/10.1016/s0014-5793(02)03013-2" @default.
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