FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076448619> ?p ?o ?g. }

• W2076448619 endingPage "2173" @default.
• W2076448619 startingPage "2161" @default.
• W2076448619 abstract "Pig islets demonstrate significantly lower insulin secretion after glucose stimulation than human islets (stimulation index of ~12 vs. 2 for glucose 1 and 15 mM, respectively) due to a major difference in β- and α-cell composition in islets (60% and 25% in humans and 90% and 8% in pigs, respectively). This leads to a lower rise in 3′,5′-cyclic adenosine monophosphate (cAMP) in pig β-cells. Since glucagon is the major hormonal effector of cAMP in β-cells, we modified pig islet structure in vivo to increase the proportion of α-cells per islet and to improve insulin secretion. Selected doses (0, 30, 50, 75, and 100 mg/kg) of streptozotocin (STZ) were intravenously injected in 32 young pigs to assess pancreatic (insulin and glucagon) hormone levels, islet remodeling (histomorphometry for α- and β-cell proportions), and insulin and glucagon secretion in isolated islets. Endocrine structure and hormonal content of pig islets were compared with those of human islets. The dose of STZ was significantly correlated with reductions in pancreatic insulin content ( p < 0.05, r 2 = 0.77) and the proportion of β-cells ( p < 0.05, r 2 = 0.88). A maximum of 50 mg/kg STZ was required for optimal structure remodeling, with an increased proportion of α-cells per islet (26% vs. 48% α-cells per islet for STZ <50 mg/kg vs. >75 mg/kg; p < 0.05) without β-cell dysfunction. Three months after STZ treatment (30/50 mg/kg STZ), pig islets were isolated and compared with isolated control islets (0 mg/kg STZ). Isolated islets from STZ-treated (30/50 mg/kg) pigs had a higher proportion of α-cells than those from control animals (32.0% vs. 9.6%, respectively, p < 0.05). After in vitro stimulation, isolated islets from STZ-treated pigs demonstrated significantly higher glucagon content (65.4 vs. 21.0 ng/ml, p < 0.05) and insulin release (144 μU/ml) than nontreated islets (59 μU/ml, p < 0.05), respectively. Low-dose STZ (<50 mg/kg) can modify the structure of pig islets in vivo and improve insulin secretion after isolation." @default.
• W2076448619 created "2016-06-24" @default.
• W2076448619 creator A5018210050 @default.
• W2076448619 creator A5040582776 @default.
• W2076448619 creator A5048109458 @default.
• W2076448619 creator A5056159608 @default.
• W2076448619 creator A5070859698 @default.
• W2076448619 creator A5087323182 @default.
• W2076448619 date "2013-11-01" @default.
• W2076448619 modified "2023-10-16" @default.
• W2076448619 title "Improvement of Pig Islet Function by In Vivo Pancreatic Tissue Remodeling: A “Human-Like” Pig Islet Structure with Streptozotocin Treatment" @default.
• W2076448619 cites W1518831632 @default.
• W2076448619 cites W1645822270 @default.
• W2076448619 cites W1964872621 @default.
• W2076448619 cites W1965512016 @default.
• W2076448619 cites W1975327695 @default.
• W2076448619 cites W1995101370 @default.
• W2076448619 cites W2007034510 @default.
• W2076448619 cites W2008227148 @default.
• W2076448619 cites W2009291798 @default.
• W2076448619 cites W2009452514 @default.
• W2076448619 cites W2014171047 @default.
• W2076448619 cites W2016124159 @default.
• W2076448619 cites W2020458810 @default.
• W2076448619 cites W2023556678 @default.
• W2076448619 cites W2025659430 @default.
• W2076448619 cites W2056018177 @default.
• W2076448619 cites W2061009859 @default.
• W2076448619 cites W2066613346 @default.
• W2076448619 cites W2074332806 @default.
• W2076448619 cites W2074528335 @default.
• W2076448619 cites W2075307702 @default.
• W2076448619 cites W2078983304 @default.
• W2076448619 cites W2083731696 @default.
• W2076448619 cites W2084770187 @default.
• W2076448619 cites W2096519012 @default.
• W2076448619 cites W2108040825 @default.
• W2076448619 cites W2108841123 @default.
• W2076448619 cites W2112662561 @default.
• W2076448619 cites W2112754594 @default.
• W2076448619 cites W2120634516 @default.
• W2076448619 cites W2143485814 @default.
• W2076448619 cites W2165817281 @default.
• W2076448619 cites W2246025446 @default.
• W2076448619 cites W2322125760 @default.
• W2076448619 cites W2323566388 @default.
• W2076448619 cites W2328786770 @default.
• W2076448619 cites W2433290023 @default.
• W2076448619 doi "https://doi.org/10.3727/096368912x657864" @default.
• W2076448619 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23051152" @default.
• W2076448619 hasPublicationYear "2013" @default.
• W2076448619 type Work @default.
• W2076448619 sameAs 2076448619 @default.
• W2076448619 citedByCount "3" @default.
• W2076448619 countsByYear W20764486192017 @default.
• W2076448619 countsByYear W20764486192020 @default.
• W2076448619 crossrefType "journal-article" @default.
• W2076448619 hasAuthorship W2076448619A5018210050 @default.
• W2076448619 hasAuthorship W2076448619A5040582776 @default.
• W2076448619 hasAuthorship W2076448619A5048109458 @default.
• W2076448619 hasAuthorship W2076448619A5056159608 @default.
• W2076448619 hasAuthorship W2076448619A5070859698 @default.
• W2076448619 hasAuthorship W2076448619A5087323182 @default.
• W2076448619 hasConcept C126322002 @default.
• W2076448619 hasConcept C134018914 @default.
• W2076448619 hasConcept C150903083 @default.
• W2076448619 hasConcept C165220095 @default.
• W2076448619 hasConcept C185592680 @default.
• W2076448619 hasConcept C207001950 @default.
• W2076448619 hasConcept C2778563252 @default.
• W2076448619 hasConcept C2779280383 @default.
• W2076448619 hasConcept C2779306644 @default.
• W2076448619 hasConcept C2779855799 @default.
• W2076448619 hasConcept C555293320 @default.
• W2076448619 hasConcept C71315377 @default.
• W2076448619 hasConcept C71924100 @default.
• W2076448619 hasConcept C86803240 @default.
• W2076448619 hasConceptScore W2076448619C126322002 @default.
• W2076448619 hasConceptScore W2076448619C134018914 @default.
• W2076448619 hasConceptScore W2076448619C150903083 @default.
• W2076448619 hasConceptScore W2076448619C165220095 @default.
• W2076448619 hasConceptScore W2076448619C185592680 @default.
• W2076448619 hasConceptScore W2076448619C207001950 @default.
• W2076448619 hasConceptScore W2076448619C2778563252 @default.
• W2076448619 hasConceptScore W2076448619C2779280383 @default.
• W2076448619 hasConceptScore W2076448619C2779306644 @default.
• W2076448619 hasConceptScore W2076448619C2779855799 @default.
• W2076448619 hasConceptScore W2076448619C555293320 @default.
• W2076448619 hasConceptScore W2076448619C71315377 @default.
• W2076448619 hasConceptScore W2076448619C71924100 @default.
• W2076448619 hasConceptScore W2076448619C86803240 @default.
• W2076448619 hasIssue "11" @default.
• W2076448619 hasLocation W20764486191 @default.
• W2076448619 hasLocation W20764486192 @default.
• W2076448619 hasOpenAccess W2076448619 @default.
• W2076448619 hasPrimaryLocation W20764486191 @default.
• W2076448619 hasRelatedWork W1979097447 @default.
• W2076448619 hasRelatedWork W1984592363 @default.

• next