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- W2076452392 abstract "Aneuploidy, an incorrect chromosome number, is a hallmark of cancer. Compounds that cause lethality in aneuploid, but not euploid, cells could therefore provide new cancer therapies. We have identified the energy stress-inducing agent AICAR, the protein folding inhibitor 17-AAG, and the autophagy inhibitor chloroquine as exhibiting this property. AICAR induces p53-mediated apoptosis in primary mouse embryonic fibroblasts (MEFs) trisomic for chromosome 1, 13, 16, or 19. AICAR and 17-AAG, especially when combined, also show efficacy against aneuploid human cancer cell lines. Our results suggest that compounds that interfere with pathways that are essential for the survival of aneuploid cells could serve as a new treatment strategy against a broad spectrum of human tumors." @default.
- W2076452392 created "2016-06-24" @default.
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- W2076452392 date "2011-02-01" @default.
- W2076452392 modified "2023-10-14" @default.
- W2076452392 title "Identification of Aneuploidy-Selective Antiproliferation Compounds" @default.
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- W2076452392 doi "https://doi.org/10.1016/j.cell.2011.01.017" @default.
- W2076452392 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3532042" @default.
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