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- W2076453500 abstract "Abstract Amyloid precursor protein (APP) is best known for its involvement in the pathogenesis of Alzheimer’s disease. We have previously demonstrated that APP intracellular domain (AICD) regulates neurogenesis; however, the mechanisms underlying AICD-mediated regulation of neuronal differentiation are not yet fully characterized. Using genome-wide chromatin immunoprecipitation approaches, we found that AICD is specifically recruited to the regulatory regions of several microRNA genes, and acts as a transcriptional regulator for miR-663, miR-3648 and miR-3687 in human neural stem cells. Functional assays show that AICD negatively modulates neuronal differentiation through miR-663, a primate-specific microRNA. Microarray data further demonstrate that miR-663 suppresses the expression of multiple genes implicated in neurogenesis, including FBXL18 and CDK6 . Our results indicate that AICD has a novel role in suppression of neuronal differentiation via transcriptional regulation of miR-663 in human neural stem cells." @default.
- W2076453500 created "2016-06-24" @default.
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- W2076453500 date "2015-02-19" @default.
- W2076453500 modified "2023-10-09" @default.
- W2076453500 title "APP intracellular domain acts as a transcriptional regulator of miR-663 suppressing neuronal differentiation" @default.
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- W2076453500 doi "https://doi.org/10.1038/cddis.2015.10" @default.
- W2076453500 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4669786" @default.
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