FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076455180> ?p ?o ?g. }

• W2076455180 endingPage "1355" @default.
• W2076455180 startingPage "1351" @default.
• W2076455180 abstract "The influx transport mechanism of pentazocine (PTZ) at the blood-brain barrier (BBB) was investigated in rats using the carotid injection technique. The uptake kinetics of PTZ into the rat brain exhibited saturability, which occurred by both nonsaturable and carrier-mediated transport processes. The in vivo kinetic parameters were estimated as follows: the maximal uptake rate (Jmax), 3.6 +/- 1.2 micromol/min/g brain and the apparent Michaelis constant (K1), 3.7 +/- 1.7 mM for the saturable component of PTZ into the brain, and the nonsaturable uptake rate constant (Kd), 0.06 +/- 0.04 ml/min/g brain. The uptake of PTZ by the brain was strongly inhibited by lidocaine, imipramine and propranolol, and also by H1-antagonists such as mepyramine, diphenhydramine. In addition, narcotic-antagonist analgesic (buprenorphine, butorphanol or eptazocine) and an opioid antagonist (naloxone) significantly inhibited PTZ transport. These results suggest that PTZ permeates into the brain via a carrier-mediated transport system, which may widely recognize the cationic drugs." @default.
• W2076455180 created "2016-06-24" @default.
• W2076455180 creator A5004246908 @default.
• W2076455180 creator A5015550264 @default.
• W2076455180 creator A5056679149 @default.
• W2076455180 creator A5068510914 @default.
• W2076455180 creator A5071626040 @default.
• W2076455180 creator A5072348958 @default.
• W2076455180 date "2002-01-01" @default.
• W2076455180 modified "2023-10-12" @default.
• W2076455180 title "Investigation on the Influx Transport Mechanism of Pentazocine at the Blood-Brain Barrier in Rats Using the Carotid Injection Technique." @default.
• W2076455180 cites W1489050546 @default.
• W2076455180 cites W1569290580 @default.
• W2076455180 cites W16537224 @default.
• W2076455180 cites W1931940324 @default.
• W2076455180 cites W2012799954 @default.
• W2076455180 cites W2040488706 @default.
• W2076455180 cites W2047219680 @default.
• W2076455180 cites W2049382175 @default.
• W2076455180 cites W2067223842 @default.
• W2076455180 cites W2077128425 @default.
• W2076455180 cites W2083093247 @default.
• W2076455180 cites W2083192703 @default.
• W2076455180 cites W2084670469 @default.
• W2076455180 cites W2257064175 @default.
• W2076455180 cites W2324032557 @default.
• W2076455180 cites W319220599 @default.
• W2076455180 doi "https://doi.org/10.1248/bpb.25.1351" @default.
• W2076455180 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12392093" @default.
• W2076455180 hasPublicationYear "2002" @default.
• W2076455180 type Work @default.
• W2076455180 sameAs 2076455180 @default.
• W2076455180 citedByCount "19" @default.
• W2076455180 countsByYear W20764551802013 @default.
• W2076455180 countsByYear W20764551802014 @default.
• W2076455180 countsByYear W20764551802017 @default.
• W2076455180 countsByYear W20764551802019 @default.
• W2076455180 countsByYear W20764551802021 @default.
• W2076455180 crossrefType "journal-article" @default.
• W2076455180 hasAuthorship W2076455180A5004246908 @default.
• W2076455180 hasAuthorship W2076455180A5015550264 @default.
• W2076455180 hasAuthorship W2076455180A5056679149 @default.
• W2076455180 hasAuthorship W2076455180A5068510914 @default.
• W2076455180 hasAuthorship W2076455180A5071626040 @default.
• W2076455180 hasAuthorship W2076455180A5072348958 @default.
• W2076455180 hasBestOaLocation W20764551801 @default.
• W2076455180 hasConcept C134018914 @default.
• W2076455180 hasConcept C150903083 @default.
• W2076455180 hasConcept C170493617 @default.
• W2076455180 hasConcept C185592680 @default.
• W2076455180 hasConcept C207001950 @default.
• W2076455180 hasConcept C2776885963 @default.
• W2076455180 hasConcept C2777389121 @default.
• W2076455180 hasConcept C2778402981 @default.
• W2076455180 hasConcept C2778750930 @default.
• W2076455180 hasConcept C2779090179 @default.
• W2076455180 hasConcept C2780802079 @default.
• W2076455180 hasConcept C42219234 @default.
• W2076455180 hasConcept C529278444 @default.
• W2076455180 hasConcept C55493867 @default.
• W2076455180 hasConcept C71924100 @default.
• W2076455180 hasConcept C86803240 @default.
• W2076455180 hasConcept C98274493 @default.
• W2076455180 hasConceptScore W2076455180C134018914 @default.
• W2076455180 hasConceptScore W2076455180C150903083 @default.
• W2076455180 hasConceptScore W2076455180C170493617 @default.
• W2076455180 hasConceptScore W2076455180C185592680 @default.
• W2076455180 hasConceptScore W2076455180C207001950 @default.
• W2076455180 hasConceptScore W2076455180C2776885963 @default.
• W2076455180 hasConceptScore W2076455180C2777389121 @default.
• W2076455180 hasConceptScore W2076455180C2778402981 @default.
• W2076455180 hasConceptScore W2076455180C2778750930 @default.
• W2076455180 hasConceptScore W2076455180C2779090179 @default.
• W2076455180 hasConceptScore W2076455180C2780802079 @default.
• W2076455180 hasConceptScore W2076455180C42219234 @default.
• W2076455180 hasConceptScore W2076455180C529278444 @default.
• W2076455180 hasConceptScore W2076455180C55493867 @default.
• W2076455180 hasConceptScore W2076455180C71924100 @default.
• W2076455180 hasConceptScore W2076455180C86803240 @default.
• W2076455180 hasConceptScore W2076455180C98274493 @default.
• W2076455180 hasIssue "10" @default.
• W2076455180 hasLocation W20764551801 @default.
• W2076455180 hasLocation W20764551802 @default.
• W2076455180 hasOpenAccess W2076455180 @default.
• W2076455180 hasPrimaryLocation W20764551801 @default.
• W2076455180 hasRelatedWork W1983177446 @default.
• W2076455180 hasRelatedWork W1999331825 @default.
• W2076455180 hasRelatedWork W2032593308 @default.
• W2076455180 hasRelatedWork W2039102254 @default.
• W2076455180 hasRelatedWork W2060863279 @default.
• W2076455180 hasRelatedWork W2062633284 @default.
• W2076455180 hasRelatedWork W2269515678 @default.
• W2076455180 hasRelatedWork W2402061517 @default.
• W2076455180 hasRelatedWork W4251938809 @default.
• W2076455180 hasRelatedWork W65665098 @default.
• W2076455180 hasVolume "25" @default.
• W2076455180 isParatext "false" @default.
• W2076455180 isRetracted "false" @default.

• next