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• W2076455635 abstract "BACKGROUND: Mechanisms underlying the development of noncommunicating syringomyelia are poorly understood. OBJECTIVE: To assess the influence of focal arachnoiditis and central canal (CC) occlusion (CCO) on the formation of noncommunicating syringomyelia in the adult rat cervical spinal cord. Expression of pericanalicular aquaporin-4 is also examined. METHODS: Sprague-Dawley rats were subjected to circumferential or dorsal arachnoiditis (n = 34). Rats undergoing CCO (n = 69) were divided into 4 groups: group A, kaolin injection at a single site in the dorsal columns near the CC; group B, kaolin injection at multiple sites in the dorsal columns near the CC; group C, saline injection at multiple sites in the dorsal columns near the CC; or group D, controls. Rats were killed at 1, 4, 8, and 12 weeks. The CC area and aquaporin-4 (AQP4) expression were measured at the level of maximal CC enlargement. RESULTS: Circumferential and dorsal arachnoiditis induced a mild increase in the CC area at 12 weeks. Single-site CCO induced slight CC enlargement. In contrast, multiple sites of CCO in proximity frequently induced a major expansion of the CC area (up to 50 times). Increased AQP4 expression was observed in pericanalicular astrocytes proportional to the degree of CC expansion. CONCLUSION: Multiple sites of CCO created a model of noncommunicating syringomyelia in adult rats. Increased astrocytic AQP4 expression was proportional to the degree of CC expansion. Modulation of aquaporin expression may be a novel target for therapeutic interventions to prevent syringomyelia. ABBREVIATIONS: AQP, aquaporin CC, central canal CCO, central canal occlusion PBS, phosphate-buffered saline PTS, posttraumatic syringomyelia SCI, spinal cord injury SM, syringomyelia" @default.
• W2076455635 created "2016-06-24" @default.
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• W2076455635 date "2012-07-01" @default.
• W2076455635 modified "2023-09-26" @default.
• W2076455635 title "Cervical Central Canal Occlusion Induces Noncommunicating Syringomyelia" @default.
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• W2076455635 doi "https://doi.org/10.1227/neu.0b013e31824d18ae" @default.
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