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- W2076456265 abstract "The plaque-forming cell (PFC) response of C57BL/6 mice to NP-coupled sheep red blood cells can be inhibited by administration of microgram doses of a variety of monoclonal anti-NP antibodies of various isotypes prior to immunization. NP-specific PFC are most strongly affected but a drastic reduction of the SRC-specific response also occurs. The latter depends on physical association of the immunizing red cells with NP groups. Inhibition was obtained with antibodies of all IgG subclasses, but was marginal or absent when up to 100 μg IgM or IgD antibodies or F(ab′)2 fragments were administered. Our experiments lead us to conclude that antibody feedback inhibition is not the function of a particular IgG subclass and that the role of the variable region in feedback inhibition is sufficiently explained by its affinity for the antigen. It was noted that small doses of a monoclonal NP-specific IgM antibody failed to enhance the response to NP-SRC." @default.
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- W2076456265 date "1982-08-01" @default.
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- W2076456265 title "Regulation of the antibody response against hapten-coupled erythrocytes by monoclonal antihapten antibodies of various isotypes" @default.
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- W2076456265 doi "https://doi.org/10.1016/0008-8749(82)90270-2" @default.
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