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• W2076457965 endingPage "1617" @default.
• W2076457965 startingPage "1614" @default.
• W2076457965 abstract "The tumor suppressor PTEN is a phosphatase with sequence similarity to the cytoskeletal protein tensin. Here the cellular roles of PTEN were investigated. Overexpression of PTEN inhibited cell migration, whereas antisense PTEN enhanced migration. Integrin-mediated cell spreading and the formation of focal adhesions were down-regulated by wild-type PTEN but not by PTEN with an inactive phosphatase domain. PTEN interacted with the focal adhesion kinase FAK and reduced its tyrosine phosphorylation. Overexpression of FAK partially antagonized the effects of PTEN. Thus, PTEN phosphatase may function as a tumor suppressor by negatively regulating cell interactions with the extracellular matrix." @default.
• W2076457965 created "2016-06-24" @default.
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• W2076457965 date "1998-06-05" @default.
• W2076457965 modified "2023-10-10" @default.
• W2076457965 title "Inhibition of Cell Migration, Spreading, and Focal Adhesions by Tumor Suppressor PTEN" @default.
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• W2076457965 doi "https://doi.org/10.1126/science.280.5369.1614" @default.
• W2076457965 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9616126" @default.
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