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• W2076459281 abstract "Thirty-five children with short-stature underwent insulin-loading and sleep tests for assessment of secretion of human growth hormone. Correlations between the levels of human growth hormone in the serum and urine during the tests were examined to elucidate the clinical significance of urinary human growth hormone levels in short children. The concentration and total amount of human growth hormone in the urine correlated significantly with the peak concentration of serum human growth hormone (r=0.81, p<0.001 and r=0.80, p<0.001, respectively) and the integrated concentration of human growth hormone (r=0.85, p<0.001 and r=0.85, p<0.001, respectively) in the insulin-loading test. The concentration and total amount of human growth hormone in the morning urine also correlated significantly with the peak concentration of serum human growth hormone (r=0.80, p<0.001 and r=0.70, p<0.001, respectively) and the integrated concentration of serum human growth hormone (r=0.80, p<0.001 and r=0.72, p<0.001, respectively) in the sleep test. The concentration or total amount of human growth hormone in the urine differed significantly among children with human growth hormone deficiency, those with nonendocrine short stature, and those with normal stature (p<0.05). These data suggest that measurement of human growth hormone in the urine may be used to assess secretion of human growth hormone, serving as a screening test for human growth hormone deficiency in children. Thirty-five children with short-stature underwent insulin-loading and sleep tests for assessment of secretion of human growth hormone. Correlations between the levels of human growth hormone in the serum and urine during the tests were examined to elucidate the clinical significance of urinary human growth hormone levels in short children. The concentration and total amount of human growth hormone in the urine correlated significantly with the peak concentration of serum human growth hormone (r=0.81, p<0.001 and r=0.80, p<0.001, respectively) and the integrated concentration of human growth hormone (r=0.85, p<0.001 and r=0.85, p<0.001, respectively) in the insulin-loading test. The concentration and total amount of human growth hormone in the morning urine also correlated significantly with the peak concentration of serum human growth hormone (r=0.80, p<0.001 and r=0.70, p<0.001, respectively) and the integrated concentration of serum human growth hormone (r=0.80, p<0.001 and r=0.72, p<0.001, respectively) in the sleep test. The concentration or total amount of human growth hormone in the urine differed significantly among children with human growth hormone deficiency, those with nonendocrine short stature, and those with normal stature (p<0.05). These data suggest that measurement of human growth hormone in the urine may be used to assess secretion of human growth hormone, serving as a screening test for human growth hormone deficiency in children." @default.
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• W2076459281 date "1992-02-01" @default.
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• W2076459281 title "Urinary excretion of human growth hormone in children with short stature: Correlation with pituitary secretion of human growth hormone" @default.
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• W2076459281 doi "https://doi.org/10.1016/s0022-3476(05)80433-0" @default.
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