FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076467232> ?p ?o ?g. }

• W2076467232 endingPage "706" @default.
• W2076467232 startingPage "700" @default.
• W2076467232 abstract "( Cancer Sci 2010; 101: 700–706) Wnt signaling plays key roles in development, cell growth, differentiation, polarity formation, neural development, and carcinogenesis. DIX Domain Containing 1 ( DIXDC 1 ), a novel component of the Wnt pathway, was recently cloned. DIXDC1 is the human homolog of Ccd1, a positive regulator of the Wnt signaling pathway during zebrafish neural patterning. Little has been known about DIXDC1 gene expression regulation. In the present study, we showed that the DIXDC1 protein was induced upon Wnt‐3a stimulation, whereas the DIXDC1 mRNA level was not significantly increased after Wnt‐3a treatment. Positive DIXDC1 staining was detected in colon cancer cells and was colocalized with β‐catenin staining. However, the DIXDC1 mRNA expression decreased in human colon cancer cells compared to the matched normal colon epithelial cells. Our further investigation showed that the DIXDC1 protein was degraded through the proteasome pathway, and the activation of canonical Wnt signaling decreased the ubiquitin‐dependent degradation of both the ectopic and endogenous DIXDC1 protein. In order to explore the possible mechanism of the ubiquitination of DIXDC1, we found that the phosphorylation of DIXDC1 was inhibited by Wnt‐3a. Collectively, these results indicate that canonical Wnt/β‐catenin pathway activation might upregulate DIXDC1 through a post‐translational mechanism by inhibiting the ubiquitin‐mediated degradation of the DIXDC1 protein." @default.
• W2076467232 created "2016-06-24" @default.
• W2076467232 creator A5000952365 @default.
• W2076467232 creator A5002110596 @default.
• W2076467232 creator A5046980371 @default.
• W2076467232 creator A5056975844 @default.
• W2076467232 creator A5073216396 @default.
• W2076467232 creator A5079572607 @default.
• W2076467232 date "2010-02-17" @default.
• W2076467232 modified "2023-10-18" @default.
• W2076467232 title "Wnt signaling stabilizes the DIXDC1 protein through decreased ubiquitin-dependent degradation" @default.
• W2076467232 cites W1973223773 @default.
• W2076467232 cites W1975853332 @default.
• W2076467232 cites W1990000762 @default.
• W2076467232 cites W1991528567 @default.
• W2076467232 cites W2000828354 @default.
• W2076467232 cites W2005157390 @default.
• W2076467232 cites W2019133693 @default.
• W2076467232 cites W2023407460 @default.
• W2076467232 cites W2029857102 @default.
• W2076467232 cites W2031134923 @default.
• W2076467232 cites W2033106726 @default.
• W2076467232 cites W2040942754 @default.
• W2076467232 cites W2044890294 @default.
• W2076467232 cites W2045609454 @default.
• W2076467232 cites W2061572587 @default.
• W2076467232 cites W2062096656 @default.
• W2076467232 cites W2081985759 @default.
• W2076467232 cites W2085600937 @default.
• W2076467232 cites W2086320165 @default.
• W2076467232 cites W2090851532 @default.
• W2076467232 cites W2091605975 @default.
• W2076467232 cites W2095424116 @default.
• W2076467232 cites W2128239138 @default.
• W2076467232 cites W2155507705 @default.
• W2076467232 cites W2166440816 @default.
• W2076467232 cites W2166987747 @default.
• W2076467232 doi "https://doi.org/10.1111/j.1349-7006.2009.01448.x" @default.
• W2076467232 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20085589" @default.
• W2076467232 hasPublicationYear "2010" @default.
• W2076467232 type Work @default.
• W2076467232 sameAs 2076467232 @default.
• W2076467232 citedByCount "13" @default.
• W2076467232 countsByYear W20764672322012 @default.
• W2076467232 countsByYear W20764672322013 @default.
• W2076467232 countsByYear W20764672322015 @default.
• W2076467232 countsByYear W20764672322016 @default.
• W2076467232 countsByYear W20764672322017 @default.
• W2076467232 countsByYear W20764672322023 @default.
• W2076467232 crossrefType "journal-article" @default.
• W2076467232 hasAuthorship W2076467232A5000952365 @default.
• W2076467232 hasAuthorship W2076467232A5002110596 @default.
• W2076467232 hasAuthorship W2076467232A5046980371 @default.
• W2076467232 hasAuthorship W2076467232A5056975844 @default.
• W2076467232 hasAuthorship W2076467232A5073216396 @default.
• W2076467232 hasAuthorship W2076467232A5079572607 @default.
• W2076467232 hasBestOaLocation W20764672321 @default.
• W2076467232 hasConcept C104317684 @default.
• W2076467232 hasConcept C121608353 @default.
• W2076467232 hasConcept C127561419 @default.
• W2076467232 hasConcept C134459356 @default.
• W2076467232 hasConcept C137620995 @default.
• W2076467232 hasConcept C170320316 @default.
• W2076467232 hasConcept C182819311 @default.
• W2076467232 hasConcept C185592680 @default.
• W2076467232 hasConcept C25602115 @default.
• W2076467232 hasConcept C27740335 @default.
• W2076467232 hasConcept C2992195973 @default.
• W2076467232 hasConcept C502942594 @default.
• W2076467232 hasConcept C54355233 @default.
• W2076467232 hasConcept C55493867 @default.
• W2076467232 hasConcept C555283112 @default.
• W2076467232 hasConcept C62478195 @default.
• W2076467232 hasConcept C86803240 @default.
• W2076467232 hasConcept C95444343 @default.
• W2076467232 hasConcept C99732316 @default.
• W2076467232 hasConceptScore W2076467232C104317684 @default.
• W2076467232 hasConceptScore W2076467232C121608353 @default.
• W2076467232 hasConceptScore W2076467232C127561419 @default.
• W2076467232 hasConceptScore W2076467232C134459356 @default.
• W2076467232 hasConceptScore W2076467232C137620995 @default.
• W2076467232 hasConceptScore W2076467232C170320316 @default.
• W2076467232 hasConceptScore W2076467232C182819311 @default.
• W2076467232 hasConceptScore W2076467232C185592680 @default.
• W2076467232 hasConceptScore W2076467232C25602115 @default.
• W2076467232 hasConceptScore W2076467232C27740335 @default.
• W2076467232 hasConceptScore W2076467232C2992195973 @default.
• W2076467232 hasConceptScore W2076467232C502942594 @default.
• W2076467232 hasConceptScore W2076467232C54355233 @default.
• W2076467232 hasConceptScore W2076467232C55493867 @default.
• W2076467232 hasConceptScore W2076467232C555283112 @default.
• W2076467232 hasConceptScore W2076467232C62478195 @default.
• W2076467232 hasConceptScore W2076467232C86803240 @default.
• W2076467232 hasConceptScore W2076467232C95444343 @default.
• W2076467232 hasConceptScore W2076467232C99732316 @default.
• W2076467232 hasIssue "3" @default.
• W2076467232 hasLocation W20764672321 @default.
• W2076467232 hasLocation W20764672322 @default.

• next