FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076467579> ?p ?o ?g. }

• W2076467579 endingPage "166" @default.
• W2076467579 startingPage "159" @default.
• W2076467579 abstract "The frequent recurrence of glioblastoma multiforme (GBM) after standard treatment with temozolomide (TMZ) is a crucial issue to be solved in the clinical field. O6‑methylguanine‑DNA methyltransferase (MGMT) is considered one of the major mechanisms involved in TMZ resistance. However, some important mechanisms for TMZ resistance other than MGMT have recently been identified. In the present study, we established a TMZ-resistant (TMZ-R) U87 glioblastoma cell line in vitro and in vivo and investigated novel targeting molecules other than MGMT in those cells. The TMZ-R U87 glioblastoma cell line was established in vitro and in vivo. TMZ-R U87 cells showed a more invasive activity and a shorter survival time in vivo. Gene expression analysis using DNA microarray and quantitative PCR (qPCR) demonstrated that YKL‑40, MAGEC1 and MGMT mRNA expression was upregulated 100-, 83- and 6-fold, respectively in the TMZ-R U87 cell line. Western blot analysis and qPCR demonstrated that STAT3 phosphorylation, STAT3 target genes and stem cell and mesenchymal marker genes were upregulated to a greater extent in the TMZ‑resistant cell line. Notably, short hairpin (sh)RNA‑based inhibition against the YKL‑40 gene resulted in moderate growth inhibition in the resistant cells in vitro and in vivo. Additionally, YKL‑40 gene inhibition exhibited significant suppression of the invasive activity and particularly partially restored the sensitivity to TMZ. Therefore, YKL‑40 may be a novel key molecule in addition to MGMT, that is responsible for TMZ resistance in glioblastoma cell lines and could be a new target to overcome TMZ resistance in recurrent glioblastomas in the future." @default.
• W2076467579 created "2016-06-24" @default.
• W2076467579 creator A5001076539 @default.
• W2076467579 creator A5006506867 @default.
• W2076467579 creator A5008993812 @default.
• W2076467579 creator A5017610115 @default.
• W2076467579 creator A5024806493 @default.
• W2076467579 creator A5043351415 @default.
• W2076467579 creator A5045433611 @default.
• W2076467579 creator A5051660736 @default.
• W2076467579 creator A5053548675 @default.
• W2076467579 creator A5056653544 @default.
• W2076467579 creator A5062822226 @default.
• W2076467579 creator A5066008987 @default.
• W2076467579 creator A5077384482 @default.
• W2076467579 date "2014-05-16" @default.
• W2076467579 modified "2023-09-29" @default.
• W2076467579 title "YKL-40 downregulation is a key factor to overcome temozolomide resistance in a glioblastoma cell line" @default.
• W2076467579 cites W1979259404 @default.
• W2076467579 cites W1982161030 @default.
• W2076467579 cites W1986103182 @default.
• W2076467579 cites W2001902450 @default.
• W2076467579 cites W2012909561 @default.
• W2076467579 cites W2027072680 @default.
• W2076467579 cites W2052883386 @default.
• W2076467579 cites W2056063307 @default.
• W2076467579 cites W2074167295 @default.
• W2076467579 cites W2096287682 @default.
• W2076467579 cites W2099776053 @default.
• W2076467579 cites W2105100844 @default.
• W2076467579 cites W2108960802 @default.
• W2076467579 cites W2110034822 @default.
• W2076467579 cites W2110265246 @default.
• W2076467579 cites W2113729674 @default.
• W2076467579 cites W2113942802 @default.
• W2076467579 cites W2115785123 @default.
• W2076467579 cites W2121585125 @default.
• W2076467579 cites W2121625674 @default.
• W2076467579 cites W2122521556 @default.
• W2076467579 cites W2124657377 @default.
• W2076467579 cites W2125758259 @default.
• W2076467579 cites W2135556874 @default.
• W2076467579 cites W2138545604 @default.
• W2076467579 cites W2158370459 @default.
• W2076467579 cites W2161289668 @default.
• W2076467579 cites W2162617260 @default.
• W2076467579 cites W2164762451 @default.
• W2076467579 doi "https://doi.org/10.3892/or.2014.3195" @default.
• W2076467579 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24842123" @default.
• W2076467579 hasPublicationYear "2014" @default.
• W2076467579 type Work @default.
• W2076467579 sameAs 2076467579 @default.
• W2076467579 citedByCount "30" @default.
• W2076467579 countsByYear W20764675792014 @default.
• W2076467579 countsByYear W20764675792015 @default.
• W2076467579 countsByYear W20764675792016 @default.
• W2076467579 countsByYear W20764675792017 @default.
• W2076467579 countsByYear W20764675792018 @default.
• W2076467579 countsByYear W20764675792019 @default.
• W2076467579 countsByYear W20764675792020 @default.
• W2076467579 countsByYear W20764675792021 @default.
• W2076467579 countsByYear W20764675792022 @default.
• W2076467579 countsByYear W20764675792023 @default.
• W2076467579 crossrefType "journal-article" @default.
• W2076467579 hasAuthorship W2076467579A5001076539 @default.
• W2076467579 hasAuthorship W2076467579A5006506867 @default.
• W2076467579 hasAuthorship W2076467579A5008993812 @default.
• W2076467579 hasAuthorship W2076467579A5017610115 @default.
• W2076467579 hasAuthorship W2076467579A5024806493 @default.
• W2076467579 hasAuthorship W2076467579A5043351415 @default.
• W2076467579 hasAuthorship W2076467579A5045433611 @default.
• W2076467579 hasAuthorship W2076467579A5051660736 @default.
• W2076467579 hasAuthorship W2076467579A5053548675 @default.
• W2076467579 hasAuthorship W2076467579A5056653544 @default.
• W2076467579 hasAuthorship W2076467579A5062822226 @default.
• W2076467579 hasAuthorship W2076467579A5066008987 @default.
• W2076467579 hasAuthorship W2076467579A5077384482 @default.
• W2076467579 hasBestOaLocation W20764675791 @default.
• W2076467579 hasConcept C104317684 @default.
• W2076467579 hasConcept C127561419 @default.
• W2076467579 hasConcept C128473837 @default.
• W2076467579 hasConcept C1491633281 @default.
• W2076467579 hasConcept C173396325 @default.
• W2076467579 hasConcept C190232843 @default.
• W2076467579 hasConcept C207001950 @default.
• W2076467579 hasConcept C2777389519 @default.
• W2076467579 hasConcept C2778227246 @default.
• W2076467579 hasConcept C2781018059 @default.
• W2076467579 hasConcept C29537977 @default.
• W2076467579 hasConcept C502942594 @default.
• W2076467579 hasConcept C54355233 @default.
• W2076467579 hasConcept C62112901 @default.
• W2076467579 hasConcept C81885089 @default.
• W2076467579 hasConcept C86803240 @default.
• W2076467579 hasConceptScore W2076467579C104317684 @default.
• W2076467579 hasConceptScore W2076467579C127561419 @default.
• W2076467579 hasConceptScore W2076467579C128473837 @default.
• W2076467579 hasConceptScore W2076467579C1491633281 @default.

• next