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• W2076480914 abstract "The present study examined caspase activation and its modulation by nitric oxide (NO) in a model of oxidative stress induced by injection of malonate (3 micromol), a mitochondrial toxin, into rat striatum. Caspase-3-like enzymatic activity was maximal 6 h after malonate while NO production evaluated by its metabolites nitrites and nitrates was increased at 3 h. The neuronal NO-synthase inhibitor 7-nitroindazole reduced malonate induced-NO production by 50% at 25 mg/kg and enhanced by 32% caspase activation. This result suggests that a moderate production of NO potentiates caspase activation, an effect counterbalanced by NO itself at higher concentrations. Accordingly, complete inhibition of NO production by 7-nitroindazole at 50 mg/kg did not modify malonate-induced caspase activity. Thus NO production by the neuronal isoform of NO-synthase is not the major event leading to caspase activation due to malonate. However, NO seems to have pro- and anti-caspase effects that neutralize each other." @default.
• W2076480914 created "2016-06-24" @default.
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• W2076480914 date "2004-01-01" @default.
• W2076480914 modified "2023-10-01" @default.
• W2076480914 title "Biphasic modulation by nitric oxide of caspase activation due to malonate injection in rat striatum" @default.
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• W2076480914 doi "https://doi.org/10.1016/j.ejphar.2003.10.038" @default.
• W2076480914 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14729115" @default.
• W2076480914 hasPublicationYear "2004" @default.
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