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- W2076487132 abstract "Interleukin-6 (IL-6) has recently been characterized as a mediator of multiple inflammatory responses. Excessive production of this cytokine has been demonstrated in the joints of patients with rheumatoid arthritis (RA). On the other hand, anti-inflammatory effects of IL-4 have recently been demonstrated. We therefore investigated the suppressive effect of IL-4 on IL-6 production by synovial cells in patients with RA. Freshly prepared adherent rheumatoid synovial cells expressed IL-6 mRNA and spontaneously produced a large amount of IL-6 in culture. This spontaneous production of IL-6 was significantly suppressed by IL-4. The suppressive effect of IL-4 on IL-6 production was demonstrated in all patients with RA tested in this study. On the other hand, IL-6 mRNA levels already expressed in adherent synovial cells were not reduced by 1L-4 in 24 hr of culture. The suppressive effect of IL-4 on IL-6 production suggests that IL-4 is an important physiological regulator of IL-6 production in synovial cells." @default.
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- W2076487132 date "1993-01-01" @default.
- W2076487132 modified "2023-09-23" @default.
- W2076487132 title "Suppressive Effect of Interleukin-4 (IL-4) on IL-6 Production by Adherent Rheumatoid Synovial Cells" @default.
- W2076487132 doi "https://doi.org/10.1006/clin.1993.1009" @default.
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