FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076493816> ?p ?o ?g. }

• W2076493816 endingPage "1219" @default.
• W2076493816 startingPage "1213" @default.
• W2076493816 abstract "Increasing evidence suggests that chronic inflammation contributes to atherogenesis, and that acute inflammatory events cause plaque rupture, thrombosis, and myocardial infarction. The present studies examined how inflammatory factors, such as interferon-gamma (IFNgamma), cause increased sensitivity to apoptosis in vascular lesion cells.Cells from the fibrous cap of human atherosclerotic lesions were sensitized by interferon-gamma (IFNgamma) to Fas-induced apoptosis, in a Bcl-X(L) reversible manner. Microarray profiling identified 72 INFgamma-induced transcripts with potential relevance to apoptosis. Half could be excluded because they were induced by IRF-1 overexpression, which did not sensitize to apoptosis. IFNgamma treatment strongly reduced Mcl-1, phospho-Bcl-2 (ser70), and phospho-Bcl-X(L) (ser62) protein levels. Candidate transcripts were modulated by siRNA, overexpression, or inhibitors to assess the effect on IFNgamma-induced Fas sensitivity. Surprisingly, siRNA knockdown of PSMB8 (LMP7), an immunoproteasome component, reversed IFNgamma-induced sensitivity to Fas ligation and prevented Fas/IFNgamma-induced degradation of Mcl-1, but did not protect p-Bcl-2 or p-Bcl-X(L). Proteasome inhibition markedly increased Mcl-1, p-Bcl-2, and p-Bcl-X(L) levels after IFNgamma treatment.Although critical for antigen presentation, the immunoproteasome appears to be a key link between inflammatory factors and the control of vascular cell apoptosis and may thus be an important factor in plaque rupture and myocardial infarction." @default.
• W2076493816 created "2016-06-24" @default.
• W2076493816 creator A5002883210 @default.
• W2076493816 creator A5024762254 @default.
• W2076493816 creator A5037399519 @default.
• W2076493816 creator A5049582352 @default.
• W2076493816 creator A5052761636 @default.
• W2076493816 creator A5053189416 @default.
• W2076493816 creator A5058300926 @default.
• W2076493816 creator A5077422551 @default.
• W2076493816 date "2009-08-01" @default.
• W2076493816 modified "2023-09-29" @default.
• W2076493816 title "Cardiovascular Inflammation and Lesion Cell Apoptosis" @default.
• W2076493816 cites W1640850494 @default.
• W2076493816 cites W190562943 @default.
• W2076493816 cites W1970834072 @default.
• W2076493816 cites W1981568946 @default.
• W2076493816 cites W1985185561 @default.
• W2076493816 cites W1986775771 @default.
• W2076493816 cites W1987949408 @default.
• W2076493816 cites W1999814371 @default.
• W2076493816 cites W2013462019 @default.
• W2076493816 cites W2026766938 @default.
• W2076493816 cites W2037585138 @default.
• W2076493816 cites W2039617821 @default.
• W2076493816 cites W2040863926 @default.
• W2076493816 cites W2043141000 @default.
• W2076493816 cites W2049082950 @default.
• W2076493816 cites W2052867923 @default.
• W2076493816 cites W2062547838 @default.
• W2076493816 cites W2068376288 @default.
• W2076493816 cites W2072941419 @default.
• W2076493816 cites W2073290833 @default.
• W2076493816 cites W2078326860 @default.
• W2076493816 cites W2084219023 @default.
• W2076493816 cites W2086435565 @default.
• W2076493816 cites W2090846657 @default.
• W2076493816 cites W2093270469 @default.
• W2076493816 cites W2094941678 @default.
• W2076493816 cites W2104098096 @default.
• W2076493816 cites W2112807025 @default.
• W2076493816 cites W2114993600 @default.
• W2076493816 cites W2127758731 @default.
• W2076493816 cites W2135458368 @default.
• W2076493816 cites W2150141064 @default.
• W2076493816 cites W2151935214 @default.
• W2076493816 cites W2156277550 @default.
• W2076493816 cites W2160453026 @default.
• W2076493816 cites W2163856919 @default.
• W2076493816 cites W2164527341 @default.
• W2076493816 cites W2167010313 @default.
• W2076493816 cites W2170947936 @default.
• W2076493816 cites W4251274106 @default.
• W2076493816 cites W65867874 @default.
• W2076493816 doi "https://doi.org/10.1161/atvbaha.109.189407" @default.
• W2076493816 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2762196" @default.
• W2076493816 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19443843" @default.
• W2076493816 hasPublicationYear "2009" @default.
• W2076493816 type Work @default.
• W2076493816 sameAs 2076493816 @default.
• W2076493816 citedByCount "47" @default.
• W2076493816 countsByYear W20764938162012 @default.
• W2076493816 countsByYear W20764938162013 @default.
• W2076493816 countsByYear W20764938162014 @default.
• W2076493816 countsByYear W20764938162015 @default.
• W2076493816 countsByYear W20764938162016 @default.
• W2076493816 countsByYear W20764938162017 @default.
• W2076493816 countsByYear W20764938162018 @default.
• W2076493816 countsByYear W20764938162019 @default.
• W2076493816 countsByYear W20764938162020 @default.
• W2076493816 countsByYear W20764938162021 @default.
• W2076493816 countsByYear W20764938162022 @default.
• W2076493816 countsByYear W20764938162023 @default.
• W2076493816 crossrefType "journal-article" @default.
• W2076493816 hasAuthorship W2076493816A5002883210 @default.
• W2076493816 hasAuthorship W2076493816A5024762254 @default.
• W2076493816 hasAuthorship W2076493816A5037399519 @default.
• W2076493816 hasAuthorship W2076493816A5049582352 @default.
• W2076493816 hasAuthorship W2076493816A5052761636 @default.
• W2076493816 hasAuthorship W2076493816A5053189416 @default.
• W2076493816 hasAuthorship W2076493816A5058300926 @default.
• W2076493816 hasAuthorship W2076493816A5077422551 @default.
• W2076493816 hasBestOaLocation W20764938161 @default.
• W2076493816 hasConcept C142724271 @default.
• W2076493816 hasConcept C190283241 @default.
• W2076493816 hasConcept C203014093 @default.
• W2076493816 hasConcept C2776178377 @default.
• W2076493816 hasConcept C2776914184 @default.
• W2076493816 hasConcept C2778690821 @default.
• W2076493816 hasConcept C2780841837 @default.
• W2076493816 hasConcept C502942594 @default.
• W2076493816 hasConcept C55493867 @default.
• W2076493816 hasConcept C71924100 @default.
• W2076493816 hasConcept C86803240 @default.
• W2076493816 hasConceptScore W2076493816C142724271 @default.
• W2076493816 hasConceptScore W2076493816C190283241 @default.
• W2076493816 hasConceptScore W2076493816C203014093 @default.
• W2076493816 hasConceptScore W2076493816C2776178377 @default.

• next