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- W2076496475 abstract "Complex dosing regimens simulated in the literature using a universal dosing regimen were calculated with a general dosing program developed using the program CONSAM. The program provides a rapid method of calculating nonuniform dosing regimens for up to n = 3 compartments for any linear model. Subject data can also be curve fitted with the program to obtain individual subject estimates to allow for dosage optimization, which is important in a clinical setting. Examples are presented to show the use of the program in optimizing a theophylline regimen, as well as estimation of a new parameter, Cuneq(T), which is defined as the average non-steady-state drug concentration at time t for a drug with an irregular dosing interval." @default.
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- W2076496475 date "1991-04-01" @default.
- W2076496475 modified "2023-09-25" @default.
- W2076496475 title "Easy and Practical Utilization of CONSAM for Simulation, Analysis, and Optimization of Complex Dosing Regimens" @default.
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- W2076496475 doi "https://doi.org/10.1002/jps.2600800406" @default.
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