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- W2076498077 abstract "One possible contribution to neurodegeneration in Alzheimer's disease (AD) may be an enhanced degradation of tryptophan (TRP) through the kynurenine (KYN) pathway that leads to neurotoxic metabolites such as 3-hydroxykynurenine (3-HK) and quinolionic acid (QUIN). We therefore investigated whether patients with AD showed an increased production of the different TRP metabolites including 3-HK and QUIN. We measured serum levels of TRP, kynurenic acid (KYNA), 3-HK, QUIN, and picolinic acid (PIC) in 20 patients with AD, 20 patients with major depression, and 19 healthy elderly subjects with subjective cognitive impairment (SCI). Serum 3-HK levels were significantly increased in AD patients compared to the comparison groups (p<.0001), even after controlling for TRP levels and age. Serum levels of KYN and KYNA, QUIN and PIC were not different between the groups; TRP levels tended to be lower in AD patients. Our data indicate an increased production of the neurotoxic TRP metabolite 3-HK in AD. There seems to be a block in the further metabolisation of 3-HK, because levels of the downstream products QUIN and PIC were not altered in AD. It has to be resolved whether these changes reflect a peripheral marker of a disturbed TRP metabolism in the brains of AD patients or if the peripheral changes may contribute to the neurodegenerative process." @default.
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- W2076498077 date "2009-07-01" @default.
- W2076498077 modified "2023-10-16" @default.
- W2076498077 title "P3-032: Elevated 3-Hydroxykynurenine serum levels in Alzheimer's disease" @default.
- W2076498077 doi "https://doi.org/10.1016/j.jalz.2009.04.1209" @default.
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