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• W2076500219 abstract "The objective of the present work was to create an active Cry1Aa toxin showing enhanced resistance to degradation by spruce budworm (Choristoneura fumiferana) midgut proteases by mutating potential chymotrypsin and trypsin sites. Fourteen Cry1Aa mutants were created in an Escherichia coli-Bacillus shuttle vector and expressed in a crystal minus Bacillus thuringiensis host. Using spruce budworm gut juice, commercial bovine trypsin and chymotrypsin we performed protease resistance assays with Cry1Aa wild type and mutant toxins. Although many mutants showed little or no change, several mutants showed a > 2-fold increase (R543S, R566G, and F570S) up to a > 4-fold increase in toxicity (F576S), in bioassay studies against C. fumiferana. The in vitro protease resistance assay results indicated a possible involvement of other gut juice components in toxin overdigestion." @default.
• W2076500219 created "2016-06-24" @default.
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• W2076500219 date "2004-02-01" @default.
• W2076500219 modified "2023-09-23" @default.
• W2076500219 title "The Bacillus thuringiensis Cry1Aa toxin: effects of trypsin and chymotrypsin site mutations on toxicity and stability" @default.
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• W2076500219 doi "https://doi.org/10.1016/j.jip.2004.02.002" @default.
• W2076500219 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15050842" @default.
• W2076500219 hasPublicationYear "2004" @default.
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