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• W2076508431 abstract "Cancer patients are at high risk of thrombo-embolism and haemorrhage – which is exacerbated in the perioperative period. The pathogenesis of this haemostatic dysfunction is complex and involves the interplay of multiple factors. A detailed understanding of the disease pathophysiology, including mechanisms of haemostasis and laboratory assessment, is imperative in the decision making. Thrombo-embolism is an important and preventable complication of cancer surgery – with appropriate application of thromboprophylaxis. The key outstanding issues surround timing of initiation, regimen and duration of therapy. A major limitation in both our understanding and our pre-emptive management of the haemostatic dysfunction is a lack of sensitive and specific tests of haemostatic potential that can provide predictive power for risk stratification. Routine laboratory tests do not accurately recognise hyper- or hypocoagulable states, or test the clinical effects of procoagulant or anticoagulant interventions. We need further development of cellular-based assays that incorporate all the components of the haemostatic system." @default.
• W2076508431 created "2016-06-24" @default.
• W2076508431 creator A5042336840 @default.
• W2076508431 date "2013-12-01" @default.
• W2076508431 modified "2023-09-27" @default.
• W2076508431 title "Haemostatic challenges in the cancer patient: Focus on the perioperative period" @default.
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• W2076508431 doi "https://doi.org/10.1016/j.bpa.2013.09.001" @default.
• W2076508431 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24267554" @default.
• W2076508431 hasPublicationYear "2013" @default.
• W2076508431 type Work @default.
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