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- W2076508730 abstract "Vinblastine sulphate (VBLS) encapsulation by small phospholipid (mainly egg lecithin (EL)) vesicles and by large egg lecithin liposomes was studied. It is found that liposomes encapsulate 10 times more drug (∼ 2% mol fraction compared to ∼ 2%o mol fraction) than the small vesicles (60–80 nm diameter). The encapsulation of VBLS may be increased by a factor of 5 when the ab initio (in the dry lipid film) ratio VBLS/EL varies from 0.03 to 1. It is assumed that this increase is due to entrapment of segregated drug in or between the EL bilayers. The release of the entrapped drug into fresh buffer is a slow phenomenon." @default.
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- W2076508730 date "1985-05-01" @default.
- W2076508730 modified "2023-10-18" @default.
- W2076508730 title "Vinblastine sulphate encapsulation in phospholipid vesicles and liposomes" @default.
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- W2076508730 doi "https://doi.org/10.1016/0378-5173(85)90016-x" @default.
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