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• W2076510207 abstract "Purpose: To quantify the influence of age on the retinal perfusion, the authors investigated the microcirculation of the retina and optic nerve head (ONH) and the blood flow velocity in the central retinal artery (CRA). Method: The authors examined two groups of healthy volunteers. In group 1 (n = 36 eyes of 36 subjects; mean age, 41.5 ± 14.9 years), retinal and ONH microcirculation was analyzed by scanning laser Doppler flowimetry. In group 2 (n = 49 eyes from 49 subjects; mean age, 44.4 ± 15.4 years), CRA blood flow velocity was examined using pulsed Doppler sonography. Results: Blood flow velocity of the CRA showed a negative correlation to age (systolic velocity, r = -0.47, P = 0.001; diastolic velocity, r = −0.49, P = 0.001). The slope of the linear, regression was −0.62 cm/second per 10 years for systolic blood velocity and −0.51 cm/second for diastolic blood velocity. Resistivity index (RI) (RI = [systolic velocity - diastolic velocity]/systolic velocity) as a marker of the rigidity of the vessel increased significantly with age (r = 0.40, P = 0.004). The slope was 0.03 per 10 years. Retinal microcirculation (flow ωret) decreased significantly with age (r = −0.63, P = 0.00001). The slope was −34.9 [AU] per 10 years. Optic nerve head blood flow showed no significant correlation to age (r = −0.30, P = 0.071). Conclusion: The authors' data indicate that there is a significant decrease of retinal and CRA blood flow of approximately 6% to 11% per decade. Optic nerve head blood flow seems not to be influenced by age. Purpose: To quantify the influence of age on the retinal perfusion, the authors investigated the microcirculation of the retina and optic nerve head (ONH) and the blood flow velocity in the central retinal artery (CRA). Method: The authors examined two groups of healthy volunteers. In group 1 (n = 36 eyes of 36 subjects; mean age, 41.5 ± 14.9 years), retinal and ONH microcirculation was analyzed by scanning laser Doppler flowimetry. In group 2 (n = 49 eyes from 49 subjects; mean age, 44.4 ± 15.4 years), CRA blood flow velocity was examined using pulsed Doppler sonography. Results: Blood flow velocity of the CRA showed a negative correlation to age (systolic velocity, r = -0.47, P = 0.001; diastolic velocity, r = −0.49, P = 0.001). The slope of the linear, regression was −0.62 cm/second per 10 years for systolic blood velocity and −0.51 cm/second for diastolic blood velocity. Resistivity index (RI) (RI = [systolic velocity - diastolic velocity]/systolic velocity) as a marker of the rigidity of the vessel increased significantly with age (r = 0.40, P = 0.004). The slope was 0.03 per 10 years. Retinal microcirculation (flow ωret) decreased significantly with age (r = −0.63, P = 0.00001). The slope was −34.9 [AU] per 10 years. Optic nerve head blood flow showed no significant correlation to age (r = −0.30, P = 0.071). Conclusion: The authors' data indicate that there is a significant decrease of retinal and CRA blood flow of approximately 6% to 11% per decade. Optic nerve head blood flow seems not to be influenced by age." @default.
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• W2076510207 title "Influence of Age on Retinal and Optic Nerve Head Blood Circulation" @default.
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• W2076510207 doi "https://doi.org/10.1016/s0161-6420(96)30662-3" @default.
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