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• W2076515532 endingPage "24" @default.
• W2076515532 startingPage "17" @default.
• W2076515532 abstract "The JNK signaling pathway is involved in regulation of many cellular events, including growth control, transformation and programmed cell death (apoptosis). The role of JNK activation in apoptosis is highly controversial, being suggested to have a pro-apoptotic, anti-apoptotic or no role in this process. It appears that the JNK pathway functions in a cell-type and stimulus-dependent manner and its different components can sometimes play opposing roles in apoptosis. Recent studies reveal that the effect of JNK activation on apoptosis depends on the activity of other signaling pathways like the NF-kappaB pathway. Here we propose a model that can explain how activation of the JNK pathway breaks the brake on apoptosis, thereby regulating, but not initiating the apoptotic process." @default.
• W2076515532 created "2016-06-24" @default.
• W2076515532 creator A5066195792 @default.
• W2076515532 date "2002-12-20" @default.
• W2076515532 modified "2023-10-11" @default.
• W2076515532 title "Activation of the JNK signaling pathway: Breaking the brake on apoptosis" @default.
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• W2076515532 doi "https://doi.org/10.1002/bies.10204" @default.
• W2076515532 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12508278" @default.
• W2076515532 hasPublicationYear "2002" @default.
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