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- W2076519106 startingPage "340" @default.
- W2076519106 abstract "A very important question in the neuroendocrinology of stress-related disorders is why some individuals thrive and others break down under similar adverse conditions. The hypothalamic-pituitary-adrenal (HPA) axis is the central component of the stress system, displaying extensive variability in reactivity among human subjects. Common gene variants have been associated with several changes in HPA axis reactivity. These gene variants are identified in the GABA(A) receptor, the mu-opioid receptor, the serotonin transporter, catechol O-methyltransferase (COMT), monoamine oxidase (MAOA), the alpha(2)-adrenergic receptor, brain-derived neurotrophic factor and the anginotensin-converting enzyme. Most extensively studied are genetic variants of the two central corticosteroid receptors, the high-affinity mineralocorticoid receptor (MR) and the lower-affinity glucocorticoid receptor (GR). In the GR, the TthIIII, NR3C1-1, ER22/23EK, N363S, BclI and the A3669G, and in the MR, the -2 G/C and the I180V all modify HPA axis responsiveness at several levels. As a result of these genetic variants, HPA axis reactivity will be changed exposing not only the brain but the whole body to suboptimal cortisol levels during challenges. We propose that these genetic variants which modulate HPA axis reactivity are part of the genetic makeup that determines individual stress responsivity and coping style, affecting vulnerability to disease." @default.
- W2076519106 created "2016-06-24" @default.
- W2076519106 creator A5022431181 @default.
- W2076519106 date "2009-01-01" @default.
- W2076519106 modified "2023-10-16" @default.
- W2076519106 title "Single Nucleotide Polymorphisms Related to HPA Axis Reactivity" @default.
- W2076519106 cites W122792336 @default.
- W2076519106 cites W181028834 @default.
- W2076519106 cites W186179355 @default.
- W2076519106 cites W1950021792 @default.
- W2076519106 cites W1966962224 @default.
- W2076519106 cites W1969384628 @default.
- W2076519106 cites W1969973989 @default.
- W2076519106 cites W1972076907 @default.
- W2076519106 cites W1977046004 @default.
- W2076519106 cites W1979295154 @default.
- W2076519106 cites W1979343070 @default.
- W2076519106 cites W1979364313 @default.
- W2076519106 cites W1979581115 @default.
- W2076519106 cites W1988729957 @default.
- W2076519106 cites W1990356805 @default.
- W2076519106 cites W1993704473 @default.
- W2076519106 cites W1994706952 @default.
- W2076519106 cites W1997224764 @default.
- W2076519106 cites W1997402790 @default.
- W2076519106 cites W1997805881 @default.
- W2076519106 cites W1998980779 @default.
- W2076519106 cites W2003050811 @default.
- W2076519106 cites W2005668937 @default.
- W2076519106 cites W2005675827 @default.
- W2076519106 cites W2012743573 @default.
- W2076519106 cites W2014534739 @default.
- W2076519106 cites W2015357735 @default.
- W2076519106 cites W2016619393 @default.
- W2076519106 cites W2018319350 @default.
- W2076519106 cites W2024776736 @default.
- W2076519106 cites W2026863929 @default.
- W2076519106 cites W2028084470 @default.
- W2076519106 cites W2030081504 @default.
- W2076519106 cites W2033226397 @default.
- W2076519106 cites W2034860511 @default.
- W2076519106 cites W2037890645 @default.
- W2076519106 cites W2041622152 @default.
- W2076519106 cites W2041699129 @default.
- W2076519106 cites W2047217999 @default.
- W2076519106 cites W2050080282 @default.
- W2076519106 cites W2053427125 @default.
- W2076519106 cites W2053869325 @default.
- W2076519106 cites W2056613530 @default.
- W2076519106 cites W2057702283 @default.
- W2076519106 cites W2058864686 @default.
- W2076519106 cites W2059010948 @default.
- W2076519106 cites W2061318641 @default.
- W2076519106 cites W2063503224 @default.
- W2076519106 cites W2064156734 @default.
- W2076519106 cites W2066156347 @default.
- W2076519106 cites W2066397039 @default.
- W2076519106 cites W2068927082 @default.
- W2076519106 cites W2070640104 @default.
- W2076519106 cites W2074257679 @default.
- W2076519106 cites W2074802748 @default.
- W2076519106 cites W2075651951 @default.
- W2076519106 cites W2076942602 @default.
- W2076519106 cites W2078132872 @default.
- W2076519106 cites W2078678809 @default.
- W2076519106 cites W2080253238 @default.
- W2076519106 cites W2081505408 @default.
- W2076519106 cites W2082474080 @default.
- W2076519106 cites W2083816318 @default.
- W2076519106 cites W2084399551 @default.
- W2076519106 cites W2091413411 @default.
- W2076519106 cites W2094075153 @default.
- W2076519106 cites W2094260805 @default.
- W2076519106 cites W2095415768 @default.
- W2076519106 cites W2096737170 @default.
- W2076519106 cites W2102054065 @default.
- W2076519106 cites W2104786490 @default.
- W2076519106 cites W2109477769 @default.
- W2076519106 cites W2112307066 @default.
- W2076519106 cites W2115568720 @default.
- W2076519106 cites W2116629441 @default.
- W2076519106 cites W2118812285 @default.
- W2076519106 cites W2119017402 @default.
- W2076519106 cites W2120509004 @default.
- W2076519106 cites W2121419568 @default.
- W2076519106 cites W2126309037 @default.
- W2076519106 cites W2136441961 @default.
- W2076519106 cites W2142307284 @default.
- W2076519106 cites W2148731425 @default.
- W2076519106 cites W2153965794 @default.
- W2076519106 cites W2154972651 @default.
- W2076519106 cites W2163762845 @default.
- W2076519106 cites W2166401337 @default.
- W2076519106 cites W2168812261 @default.
- W2076519106 cites W2170760092 @default.
- W2076519106 cites W2271467258 @default.
- W2076519106 cites W1991062475 @default.
- W2076519106 doi "https://doi.org/10.1159/000216192" @default.