Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076519326> ?p ?o ?g. }
- W2076519326 endingPage "88" @default.
- W2076519326 startingPage "82" @default.
- W2076519326 abstract "Because traditional markers for detecting renal injury are generally insensitive and nonspecific, we tried to identify some useful biomarkers. Microarray analyses and quantitative real-time PCR using human renal tubular cells showed that the mRNA expression of VNN-1 which encodes vanin-1, increased after the exposure of these cells to organic solvents (allyl alcohol, ethylene glycol, formaldehyde, chloroform, and phenol) for 24h. The mRNA levels of other inflammation-related molecules such as monocyte chemoattractant protein 1 (MCP-1) and kidney injury molecule-1 (KIM-1) also increased after the exposure to organic solvents, although their elevations were slower than that of vanin-1. In rats treated with ethylene glycol for 3 weeks, tubular injury was detected by histological examination, but not by traditional biomarkers including serum creatinine and urinary N-acetyl-β-glucosaminidase. The mRNA levels of vanin-1 and Kim-1, but not MCP-1, significantly elevated in the renal cortices of ethylene glycol-exposed rats. On immunofluorescence analyses, vanin-1 signal was detected specifically in the renal tubules with a remarkable expression in the ethylene glycol-treated rats. As a result, compared with control group, higher urinary and serum concentrations of vanin-1 were observed in the ethylene glycol-treated group. These results suggest that vanin-1 is a useful and rapid biomarker for renal tubular injury induced by organic solvents." @default.
- W2076519326 created "2016-06-24" @default.
- W2076519326 creator A5011811795 @default.
- W2076519326 creator A5016801438 @default.
- W2076519326 creator A5036757365 @default.
- W2076519326 creator A5084010872 @default.
- W2076519326 date "2011-11-01" @default.
- W2076519326 modified "2023-10-16" @default.
- W2076519326 title "Vanin-1; a potential biomarker for nephrotoxicant-induced renal injury" @default.
- W2076519326 cites W113687629 @default.
- W2076519326 cites W1963819330 @default.
- W2076519326 cites W1964405385 @default.
- W2076519326 cites W1966210204 @default.
- W2076519326 cites W1968425658 @default.
- W2076519326 cites W1976005518 @default.
- W2076519326 cites W1978442029 @default.
- W2076519326 cites W1986347387 @default.
- W2076519326 cites W2018515734 @default.
- W2076519326 cites W2018686113 @default.
- W2076519326 cites W2027425111 @default.
- W2076519326 cites W2044431182 @default.
- W2076519326 cites W2045421375 @default.
- W2076519326 cites W2047517357 @default.
- W2076519326 cites W2057230645 @default.
- W2076519326 cites W2061564255 @default.
- W2076519326 cites W2061631515 @default.
- W2076519326 cites W2062403748 @default.
- W2076519326 cites W2063123103 @default.
- W2076519326 cites W2070388732 @default.
- W2076519326 cites W2078842991 @default.
- W2076519326 cites W2089277797 @default.
- W2076519326 cites W2112132074 @default.
- W2076519326 cites W2121264215 @default.
- W2076519326 cites W2126742055 @default.
- W2076519326 cites W2132991599 @default.
- W2076519326 cites W2136066292 @default.
- W2076519326 cites W2136279532 @default.
- W2076519326 cites W2137247074 @default.
- W2076519326 cites W2146840987 @default.
- W2076519326 cites W2149687213 @default.
- W2076519326 cites W2152434211 @default.
- W2076519326 cites W2170588662 @default.
- W2076519326 cites W4236514815 @default.
- W2076519326 cites W4241624801 @default.
- W2076519326 cites W4245957869 @default.
- W2076519326 doi "https://doi.org/10.1016/j.tox.2011.08.019" @default.
- W2076519326 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21907259" @default.
- W2076519326 hasPublicationYear "2011" @default.
- W2076519326 type Work @default.
- W2076519326 sameAs 2076519326 @default.
- W2076519326 citedByCount "55" @default.
- W2076519326 countsByYear W20765193262012 @default.
- W2076519326 countsByYear W20765193262013 @default.
- W2076519326 countsByYear W20765193262014 @default.
- W2076519326 countsByYear W20765193262015 @default.
- W2076519326 countsByYear W20765193262016 @default.
- W2076519326 countsByYear W20765193262017 @default.
- W2076519326 countsByYear W20765193262018 @default.
- W2076519326 countsByYear W20765193262019 @default.
- W2076519326 countsByYear W20765193262020 @default.
- W2076519326 countsByYear W20765193262021 @default.
- W2076519326 countsByYear W20765193262022 @default.
- W2076519326 countsByYear W20765193262023 @default.
- W2076519326 crossrefType "journal-article" @default.
- W2076519326 hasAuthorship W2076519326A5011811795 @default.
- W2076519326 hasAuthorship W2076519326A5016801438 @default.
- W2076519326 hasAuthorship W2076519326A5036757365 @default.
- W2076519326 hasAuthorship W2076519326A5084010872 @default.
- W2076519326 hasConcept C126322002 @default.
- W2076519326 hasConcept C178790620 @default.
- W2076519326 hasConcept C185592680 @default.
- W2076519326 hasConcept C2777516009 @default.
- W2076519326 hasConcept C2780091579 @default.
- W2076519326 hasConcept C2780306776 @default.
- W2076519326 hasConcept C2781197716 @default.
- W2076519326 hasConcept C55493867 @default.
- W2076519326 hasConcept C71924100 @default.
- W2076519326 hasConcept C77411442 @default.
- W2076519326 hasConceptScore W2076519326C126322002 @default.
- W2076519326 hasConceptScore W2076519326C178790620 @default.
- W2076519326 hasConceptScore W2076519326C185592680 @default.
- W2076519326 hasConceptScore W2076519326C2777516009 @default.
- W2076519326 hasConceptScore W2076519326C2780091579 @default.
- W2076519326 hasConceptScore W2076519326C2780306776 @default.
- W2076519326 hasConceptScore W2076519326C2781197716 @default.
- W2076519326 hasConceptScore W2076519326C55493867 @default.
- W2076519326 hasConceptScore W2076519326C71924100 @default.
- W2076519326 hasConceptScore W2076519326C77411442 @default.
- W2076519326 hasIssue "1" @default.
- W2076519326 hasLocation W20765193261 @default.
- W2076519326 hasLocation W20765193262 @default.
- W2076519326 hasOpenAccess W2076519326 @default.
- W2076519326 hasPrimaryLocation W20765193261 @default.
- W2076519326 hasRelatedWork W1988991907 @default.
- W2076519326 hasRelatedWork W1998670413 @default.
- W2076519326 hasRelatedWork W2067970384 @default.
- W2076519326 hasRelatedWork W2083293158 @default.
- W2076519326 hasRelatedWork W2288515854 @default.