Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076520265> ?p ?o ?g. }
- W2076520265 endingPage "216" @default.
- W2076520265 startingPage "210" @default.
- W2076520265 abstract "Whether an individual synapse releases single or multiple vesicles of transmitter per action potential is contentious and probably depends on the type of synapse. One possibility is that multivesicular release (MVR) is determined by the instantaneous release probability ( P r ) and therefore can be controlled by activity-dependent changes in P r . We investigated transmitter release across a range of P r at synapses between Schaffer collaterals (SCs) and CA1 pyramidal cells in acute hippocampal slices using patch-clamp recordings. The size of the synaptic glutamate transient was estimated by the degree of inhibition of AMPA receptor EPSCs with the rapidly equilibrating antagonist γ- d -glutamylglycine. The glutamate transient sensed by AMPA receptors depended on P r but not spillover, indicating that multiple vesicles are essentially simultaneously released from the same presynaptic active zone. Consistent with an enhanced glutamate transient, increasing P r prolonged NMDA receptor EPSCs when glutamate transporters were inhibited. We suggest that MVR occurs at SC–CA1 synapses when P r is elevated by facilitation and that MVR may be a phenomenon common to many synapses throughout the CNS." @default.
- W2076520265 created "2016-06-24" @default.
- W2076520265 creator A5012027999 @default.
- W2076520265 creator A5073211394 @default.
- W2076520265 date "2006-01-04" @default.
- W2076520265 modified "2023-10-09" @default.
- W2076520265 title "Multivesicular Release at Schaffer Collateral–CA1 Hippocampal Synapses" @default.
- W2076520265 cites W113694765 @default.
- W2076520265 cites W1517253433 @default.
- W2076520265 cites W1537179351 @default.
- W2076520265 cites W1560191661 @default.
- W2076520265 cites W1646272776 @default.
- W2076520265 cites W1845163922 @default.
- W2076520265 cites W1897919376 @default.
- W2076520265 cites W1964433270 @default.
- W2076520265 cites W1964694199 @default.
- W2076520265 cites W1965911542 @default.
- W2076520265 cites W1966765740 @default.
- W2076520265 cites W1966846060 @default.
- W2076520265 cites W1975888261 @default.
- W2076520265 cites W1981852471 @default.
- W2076520265 cites W1983245247 @default.
- W2076520265 cites W1983553517 @default.
- W2076520265 cites W1984606410 @default.
- W2076520265 cites W1988900265 @default.
- W2076520265 cites W1996667777 @default.
- W2076520265 cites W2002563632 @default.
- W2076520265 cites W2003059369 @default.
- W2076520265 cites W2006114672 @default.
- W2076520265 cites W2008146383 @default.
- W2076520265 cites W2012846394 @default.
- W2076520265 cites W2013479315 @default.
- W2076520265 cites W2020098765 @default.
- W2076520265 cites W2023654689 @default.
- W2076520265 cites W2036495604 @default.
- W2076520265 cites W2048219054 @default.
- W2076520265 cites W2050066016 @default.
- W2076520265 cites W2053273021 @default.
- W2076520265 cites W2062234159 @default.
- W2076520265 cites W2076069761 @default.
- W2076520265 cites W2089184936 @default.
- W2076520265 cites W2091448118 @default.
- W2076520265 cites W2094089753 @default.
- W2076520265 cites W2098434647 @default.
- W2076520265 cites W2100056505 @default.
- W2076520265 cites W2107092259 @default.
- W2076520265 cites W2110742628 @default.
- W2076520265 cites W2112227347 @default.
- W2076520265 cites W2112927743 @default.
- W2076520265 cites W2113832930 @default.
- W2076520265 cites W2115645299 @default.
- W2076520265 cites W2117664079 @default.
- W2076520265 cites W2120741241 @default.
- W2076520265 cites W2125659451 @default.
- W2076520265 cites W2126033464 @default.
- W2076520265 cites W2133315293 @default.
- W2076520265 cites W2146123767 @default.
- W2076520265 cites W2149394947 @default.
- W2076520265 cites W2157867129 @default.
- W2076520265 cites W2159979661 @default.
- W2076520265 cites W2169211897 @default.
- W2076520265 cites W2172073217 @default.
- W2076520265 cites W2408807018 @default.
- W2076520265 cites W2414121740 @default.
- W2076520265 cites W3021526609 @default.
- W2076520265 cites W4210958643 @default.
- W2076520265 cites W56629880 @default.
- W2076520265 doi "https://doi.org/10.1523/jneurosci.4307-05.2006" @default.
- W2076520265 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2670931" @default.
- W2076520265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16399689" @default.
- W2076520265 hasPublicationYear "2006" @default.
- W2076520265 type Work @default.
- W2076520265 sameAs 2076520265 @default.
- W2076520265 citedByCount "149" @default.
- W2076520265 countsByYear W20765202652012 @default.
- W2076520265 countsByYear W20765202652013 @default.
- W2076520265 countsByYear W20765202652014 @default.
- W2076520265 countsByYear W20765202652015 @default.
- W2076520265 countsByYear W20765202652016 @default.
- W2076520265 countsByYear W20765202652017 @default.
- W2076520265 countsByYear W20765202652018 @default.
- W2076520265 countsByYear W20765202652019 @default.
- W2076520265 countsByYear W20765202652020 @default.
- W2076520265 countsByYear W20765202652021 @default.
- W2076520265 countsByYear W20765202652022 @default.
- W2076520265 countsByYear W20765202652023 @default.
- W2076520265 crossrefType "journal-article" @default.
- W2076520265 hasAuthorship W2076520265A5012027999 @default.
- W2076520265 hasAuthorship W2076520265A5073211394 @default.
- W2076520265 hasBestOaLocation W20765202651 @default.
- W2076520265 hasConcept C112592302 @default.
- W2076520265 hasConcept C12554922 @default.
- W2076520265 hasConcept C127445978 @default.
- W2076520265 hasConcept C148762608 @default.
- W2076520265 hasConcept C154559735 @default.
- W2076520265 hasConcept C160268369 @default.
- W2076520265 hasConcept C169760540 @default.
- W2076520265 hasConcept C170493617 @default.