Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076531738> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2076531738 endingPage "236" @default.
- W2076531738 startingPage "227" @default.
- W2076531738 abstract "The level of Hb E (including Hb A2) was quantitated in 30 adult Hb E heterozygotes by cation exchange high performance liquid chromatography; in 20 subjects the a-globin gene status was determined by gene mapping and polymerase chain reaction methodology. A decrease in Hb E level was observed which was directly related to the type of a-thalassemia that was present; the lowest percentage of Hb E (and Hb A2) was 10.2%, seen in two persons with Hb Constant Spring (CS)-Hb H disease (αCSα/−). Similar analyses were made for several newborn babies with a Hb E heterozygosity; the Hb E level was determined as βE by a reversed phase high performance liquid chromatographic procedure. One baby with Hb E trait and Hb H disease (-α/−) had a βE level of 17.7% (as % of βA + βE) comparable to that seen for adults with an identical genotype. One fetus with hydrops fetalis (−/−) and Hb E trait had low βE and βA levels which, however, were nearly identical (1.5 and 1.3% of the total hemoglobin). These β chains apparently combine with the embryonic ζ chain to form Hb Portland-ll (ζ2β2A) and a variant of this hemoglobin (ζ2β2E). The affinity of the two β chains for the ζ chain must be the same and quite different from that for the α chain. Moreover, this single observation suggests an equal synthesis of βA and βE chains, the low level of Hb E in adult heterozygotes being primarily the result of a greatly decreased rate of assembly of αβE dimers." @default.
- W2076531738 created "2016-06-24" @default.
- W2076531738 creator A5087465960 @default.
- W2076531738 date "1997-01-01" @default.
- W2076531738 modified "2023-10-16" @default.
- W2076531738 title "Hb E and α-Thalassemia; Variability in the Assembly of β<sup>E</sup>Chain Containing Tetramers" @default.
- W2076531738 cites W1494573427 @default.
- W2076531738 cites W1536037468 @default.
- W2076531738 cites W1554616150 @default.
- W2076531738 cites W1783959144 @default.
- W2076531738 cites W1979222244 @default.
- W2076531738 cites W1993661194 @default.
- W2076531738 cites W2006672992 @default.
- W2076531738 cites W2011151659 @default.
- W2076531738 cites W2012170897 @default.
- W2076531738 cites W2012901225 @default.
- W2076531738 cites W2021845896 @default.
- W2076531738 cites W2026882106 @default.
- W2076531738 cites W2029073209 @default.
- W2076531738 cites W2030213956 @default.
- W2076531738 cites W2038470936 @default.
- W2076531738 cites W2040307394 @default.
- W2076531738 cites W2043275950 @default.
- W2076531738 cites W2047326946 @default.
- W2076531738 cites W2065111276 @default.
- W2076531738 cites W2077698393 @default.
- W2076531738 cites W2092340506 @default.
- W2076531738 cites W2113619357 @default.
- W2076531738 cites W2120281966 @default.
- W2076531738 cites W2151855704 @default.
- W2076531738 doi "https://doi.org/10.3109/03630269708997383" @default.
- W2076531738 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9140719" @default.
- W2076531738 hasPublicationYear "1997" @default.
- W2076531738 type Work @default.
- W2076531738 sameAs 2076531738 @default.
- W2076531738 citedByCount "18" @default.
- W2076531738 countsByYear W20765317382012 @default.
- W2076531738 countsByYear W20765317382013 @default.
- W2076531738 countsByYear W20765317382017 @default.
- W2076531738 countsByYear W20765317382022 @default.
- W2076531738 crossrefType "journal-article" @default.
- W2076531738 hasAuthorship W2076531738A5087465960 @default.
- W2076531738 hasConcept C104317684 @default.
- W2076531738 hasConcept C12125453 @default.
- W2076531738 hasConcept C125996951 @default.
- W2076531738 hasConcept C135763542 @default.
- W2076531738 hasConcept C143589142 @default.
- W2076531738 hasConcept C153471976 @default.
- W2076531738 hasConcept C153911025 @default.
- W2076531738 hasConcept C172680121 @default.
- W2076531738 hasConcept C180754005 @default.
- W2076531738 hasConcept C185592680 @default.
- W2076531738 hasConcept C2776317666 @default.
- W2076531738 hasConcept C2777674756 @default.
- W2076531738 hasConcept C2777799968 @default.
- W2076531738 hasConcept C2778917026 @default.
- W2076531738 hasConcept C2779234561 @default.
- W2076531738 hasConcept C54355233 @default.
- W2076531738 hasConcept C55493867 @default.
- W2076531738 hasConcept C86803240 @default.
- W2076531738 hasConceptScore W2076531738C104317684 @default.
- W2076531738 hasConceptScore W2076531738C12125453 @default.
- W2076531738 hasConceptScore W2076531738C125996951 @default.
- W2076531738 hasConceptScore W2076531738C135763542 @default.
- W2076531738 hasConceptScore W2076531738C143589142 @default.
- W2076531738 hasConceptScore W2076531738C153471976 @default.
- W2076531738 hasConceptScore W2076531738C153911025 @default.
- W2076531738 hasConceptScore W2076531738C172680121 @default.
- W2076531738 hasConceptScore W2076531738C180754005 @default.
- W2076531738 hasConceptScore W2076531738C185592680 @default.
- W2076531738 hasConceptScore W2076531738C2776317666 @default.
- W2076531738 hasConceptScore W2076531738C2777674756 @default.
- W2076531738 hasConceptScore W2076531738C2777799968 @default.
- W2076531738 hasConceptScore W2076531738C2778917026 @default.
- W2076531738 hasConceptScore W2076531738C2779234561 @default.
- W2076531738 hasConceptScore W2076531738C54355233 @default.
- W2076531738 hasConceptScore W2076531738C55493867 @default.
- W2076531738 hasConceptScore W2076531738C86803240 @default.
- W2076531738 hasIssue "3" @default.
- W2076531738 hasLocation W20765317381 @default.
- W2076531738 hasLocation W20765317382 @default.
- W2076531738 hasOpenAccess W2076531738 @default.
- W2076531738 hasPrimaryLocation W20765317381 @default.
- W2076531738 hasRelatedWork W1976784525 @default.
- W2076531738 hasRelatedWork W2025692077 @default.
- W2076531738 hasRelatedWork W2032038308 @default.
- W2076531738 hasRelatedWork W2041345660 @default.
- W2076531738 hasRelatedWork W2046941639 @default.
- W2076531738 hasRelatedWork W2063917967 @default.
- W2076531738 hasRelatedWork W2348954179 @default.
- W2076531738 hasRelatedWork W2474187016 @default.
- W2076531738 hasRelatedWork W4240445463 @default.
- W2076531738 hasRelatedWork W2186026359 @default.
- W2076531738 hasVolume "21" @default.
- W2076531738 isParatext "false" @default.
- W2076531738 isRetracted "false" @default.
- W2076531738 magId "2076531738" @default.
- W2076531738 workType "article" @default.