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- W2076535762 abstract "Aneuploidy might have an adverse effect on various embryo characteristics including morphology. This study involved a detailed investigation of the impact of aneuploidy on embryo morphology at different developmental stages. The copy numbers of all 24 chromosomes were evaluated. Chromosome screening and data analysis. 1256 embryos generated from 229 patients (average maternal age 39 years) were investigated. Embryo morphology was assessed and recorded on days 3 and/or 5-6 post-fertilization and chromosome analysis was carried out using microarray comparative genomic hybridisation (aCGH). At the cleavage stage aneuploidy was common even in better grade embryos (80% affected; 27% with 1 error, 23% with 2-3 errors, 30% with ≥4 errors). The majority (51%) of the best quality blastocysts were euploid. Of the good quality aneuploid blastocysts, most (34%) had 1 error, whilst only 2% had ≥4 errors. 19% of these blastocysts were affected by aneuploidies compatible with a clinical pregnancy (trisomy 13, 16, 18, 21, 22, X0, or XXY), whereas only 7% carried errors affecting larger chromosomes (1-12). 59% of cleavage stage embryos and 52% of blastocysts were females and 41% and 49% were males. However, amongst the fastest growing cleavage-stage embryos (≥10 cells) 72% were female, while the opposite was noted for rapidly developing blastocysts (grade 5 or 6; 55% males). A weak association was observed between aneuploidy and morphology at the blastocyst stage, but not earlier in development. At the cleavage stage complex abnormalities were observed in all grades, whereas this was only seen in ‘early’ blastocysts (P<0.0001). The morphology of blastocysts carrying errors affecting smaller chromosomes was similar to that of euploid embryos. This is in agreement with the fact that such aneuploid conceptions are capable of implanting and sometimes lead to clinical pregnancies and/or miscarriages. Such associations were not observed at the cleavage stage." @default.
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- W2076535762 date "2012-09-01" @default.
- W2076535762 modified "2023-10-16" @default.
- W2076535762 title "The effect of aneuploidy on embryo morphology and preimplantation development from the cleavage to the blastocyst stage" @default.
- W2076535762 doi "https://doi.org/10.1016/j.fertnstert.2012.07.605" @default.
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