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• W2076551443 abstract "The spectrum of immunogenic epitopes presented by the H2-IA(b) MHC class II molecule to CD4(+) T cells has been defined for two different (clade B and clade D) HIV envelope (gp140) glycoproteins. Hybridoma T cell lines were generated from mice immunized by a sequential prime and boost regime with DNA, recombinant vaccinia viruses, and protein. The epitopes recognized by reactive T cell hybridomas then were characterized with overlapping peptides synthesized to span the entire gp140 sequence. Evidence of clonality also was assessed with antibodies to T cell receptor Valpha and Vbeta chains. A total of 80 unique clonotypes were characterized from six individual mice. Immunogenic peptides were identified within only four regions of the HIV envelope. These epitope hotspots comprised relatively short sequences ( approximately 20-80 aa in length) that were generally bordered by regions of heavy glycosylation. Analysis in the context of the gp120 crystal structure showed a pattern of uniform distribution to exposed, nonhelical strands of the protein. A likely explanation is that the physical location of the peptide within the native protein leads to differential antigen processing and consequent epitope selection." @default.
• W2076551443 created "2016-06-24" @default.
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• W2076551443 date "2001-04-03" @default.
• W2076551443 modified "2023-10-10" @default.
• W2076551443 title "Localization of CD4⁺T cell epitope hotspots to exposed strands of HIV envelope glycoprotein suggests structural influences on antigen processing" @default.
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• W2076551443 doi "https://doi.org/10.1073/pnas.071063898" @default.
• W2076551443 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/31878" @default.
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