FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076553764> ?p ?o ?g. }

• W2076553764 endingPage "719" @default.
• W2076553764 startingPage "708" @default.
• W2076553764 abstract "Approximately 8% of clear cell renal cell carcinoma cases contain regions of radically different morphology, demonstrating a mesenchymal appearance histologically resembling sarcomas. These biphasic neoplasms are called sarcomatoid clear cell renal cell carcinoma. Patients diagnosed with sarcomatoid clear cell renal cell carcinoma face a considerably worse prognosis due to an increased propensity for metastasis. In the present study we investigate whether the sarcomatoid conversion of clear cell renal cell carcinoma could be interpreted as linked to the process of epithelial-mesenchymal transition. Using 6 biphasic clear cell renal cell carcinoma cases we show that sarcomatoid clear cell renal cell carcinoma shares characteristic markers associated with loss of von Hippel-Lindau tumor suppressor with conventional clear cell renal cell carcinoma and also exhibits a markedly higher proliferative index. Furthermore the sarcomatoid elements demonstrate an enhanced expression of epithelial-mesenchymal transition related mesenchymal markers as compared with the clear cell renal cell carcinoma counterparts. We further selected a representative case, clinically demonstrating direct overgrowth of the sarcomatoid component into the liver and colon, for extended immunohistochemical characterization, resulting in a further set of positive and negative epithelial-mesenchymal transition markers as well as pronounced transforming growth factor β positivity, indicating that sarcomatoid clear cell renal cell carcinoma may be associated to epithelial-mesenchymal transition. Transforming growth factor β1 exposure of in vitro cultured primary clear cell renal cell carcinoma cells resulted in cells adopting a mesenchymal morphology similar to sarcomatoid clear cell renal cell carcinoma. Corresponding changes in RNA levels for key epithelial-mesenchymal transition markers were also seen. We therefore suggest that sarcomatoid clear cell renal cell carcinoma morphologically and immunohistochemically may represent a completed epithelial-mesenchymal transition and that transforming growth factor β1 could be an important driving force during the sarcomatoid transdifferentiation of clear cell renal cell carcinoma." @default.
• W2076553764 created "2016-06-24" @default.
• W2076553764 creator A5020879255 @default.
• W2076553764 creator A5041420229 @default.
• W2076553764 creator A5067215547 @default.
• W2076553764 creator A5074891627 @default.
• W2076553764 creator A5077167332 @default.
• W2076553764 creator A5088250997 @default.
• W2076553764 date "2012-05-01" @default.
• W2076553764 modified "2023-10-17" @default.
• W2076553764 title "Sarcomatoid conversion of clear cell renal cell carcinoma in relation to epithelial-to-mesenchymal transition" @default.
• W2076553764 cites W129015607 @default.
• W2076553764 cites W1964081206 @default.
• W2076553764 cites W1979546548 @default.
• W2076553764 cites W1985400766 @default.
• W2076553764 cites W1987354159 @default.
• W2076553764 cites W1991973226 @default.
• W2076553764 cites W1996118868 @default.
• W2076553764 cites W2000552872 @default.
• W2076553764 cites W2011810742 @default.
• W2076553764 cites W2028275288 @default.
• W2076553764 cites W2043285040 @default.
• W2076553764 cites W2047666011 @default.
• W2076553764 cites W2048422848 @default.
• W2076553764 cites W2058536420 @default.
• W2076553764 cites W2058680827 @default.
• W2076553764 cites W2063957964 @default.
• W2076553764 cites W2074629755 @default.
• W2076553764 cites W2093405929 @default.
• W2076553764 cites W2112222526 @default.
• W2076553764 cites W2112775523 @default.
• W2076553764 cites W2131444088 @default.
• W2076553764 cites W2146119340 @default.
• W2076553764 cites W2146445411 @default.
• W2076553764 cites W2154589460 @default.
• W2076553764 cites W2161609794 @default.
• W2076553764 cites W2164584861 @default.
• W2076553764 cites W2176487712 @default.
• W2076553764 cites W4242213157 @default.
• W2076553764 cites W4250731522 @default.
• W2076553764 cites W4253186968 @default.
• W2076553764 doi "https://doi.org/10.1016/j.humpath.2011.06.019" @default.
• W2076553764 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21992819" @default.
• W2076553764 hasPublicationYear "2012" @default.
• W2076553764 type Work @default.
• W2076553764 sameAs 2076553764 @default.
• W2076553764 citedByCount "33" @default.
• W2076553764 countsByYear W20765537642013 @default.
• W2076553764 countsByYear W20765537642014 @default.
• W2076553764 countsByYear W20765537642015 @default.
• W2076553764 countsByYear W20765537642016 @default.
• W2076553764 countsByYear W20765537642017 @default.
• W2076553764 countsByYear W20765537642018 @default.
• W2076553764 countsByYear W20765537642019 @default.
• W2076553764 countsByYear W20765537642020 @default.
• W2076553764 countsByYear W20765537642021 @default.
• W2076553764 countsByYear W20765537642022 @default.
• W2076553764 countsByYear W20765537642023 @default.
• W2076553764 crossrefType "journal-article" @default.
• W2076553764 hasAuthorship W2076553764A5020879255 @default.
• W2076553764 hasAuthorship W2076553764A5041420229 @default.
• W2076553764 hasAuthorship W2076553764A5067215547 @default.
• W2076553764 hasAuthorship W2076553764A5074891627 @default.
• W2076553764 hasAuthorship W2076553764A5077167332 @default.
• W2076553764 hasAuthorship W2076553764A5088250997 @default.
• W2076553764 hasConcept C121608353 @default.
• W2076553764 hasConcept C142724271 @default.
• W2076553764 hasConcept C1491633281 @default.
• W2076553764 hasConcept C198826908 @default.
• W2076553764 hasConcept C2777472916 @default.
• W2076553764 hasConcept C2777546739 @default.
• W2076553764 hasConcept C2778560582 @default.
• W2076553764 hasConcept C2779013556 @default.
• W2076553764 hasConcept C2780808757 @default.
• W2076553764 hasConcept C2781278892 @default.
• W2076553764 hasConcept C502942594 @default.
• W2076553764 hasConcept C54355233 @default.
• W2076553764 hasConcept C71924100 @default.
• W2076553764 hasConcept C76419328 @default.
• W2076553764 hasConcept C86803240 @default.
• W2076553764 hasConceptScore W2076553764C121608353 @default.
• W2076553764 hasConceptScore W2076553764C142724271 @default.
• W2076553764 hasConceptScore W2076553764C1491633281 @default.
• W2076553764 hasConceptScore W2076553764C198826908 @default.
• W2076553764 hasConceptScore W2076553764C2777472916 @default.
• W2076553764 hasConceptScore W2076553764C2777546739 @default.
• W2076553764 hasConceptScore W2076553764C2778560582 @default.
• W2076553764 hasConceptScore W2076553764C2779013556 @default.
• W2076553764 hasConceptScore W2076553764C2780808757 @default.
• W2076553764 hasConceptScore W2076553764C2781278892 @default.
• W2076553764 hasConceptScore W2076553764C502942594 @default.
• W2076553764 hasConceptScore W2076553764C54355233 @default.
• W2076553764 hasConceptScore W2076553764C71924100 @default.
• W2076553764 hasConceptScore W2076553764C76419328 @default.
• W2076553764 hasConceptScore W2076553764C86803240 @default.
• W2076553764 hasIssue "5" @default.
• W2076553764 hasLocation W20765537641 @default.
• W2076553764 hasLocation W20765537642 @default.

• next