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• W2076554045 abstract "In Brief Lung dysfunction after cardiopulmonary bypass and lung transplantation results from oxidant-mediated cellular damage. Previously, we observed the shedding of angiotensin-converting enzyme (ACE) from the endothelial cell surface to be a more sensitive and earlier marker of oxidative lung endothelial injury than lung wet-to-dry weight ratio. The aim of this study was to evaluate the potential of the anesthetic propofol, which has antioxidant properties, to prevent oxidative lung injury by measuring ACE shedding. ACE release from isolated perfused rat lungs increased significantly after ischemia-reperfusion (I/R). Propofol significantly decreased I/R-induced ACE release by 23.4% (P < 0.05). Perfusion with 0.75 mM H2O2 also caused ACE release from the lung microvasculature, which was similarly attenuated by propofol. The protective effect of propofol on H2O2-induced ACE shedding was confirmed in vitro using Chinese Hamster Ovary cells overexpressing human ACE. Thus, propofol can attenuate oxidative injury of the pulmonary endothelium as detected by ACE shedding in I/R and H2O2 models of acute lung injury. IMPLICATIONS: Propofol attenuated oxidative lung injury induced by ischemia/reperfusion or by hydrogen peroxide in the isolated perfused rat lung. Endothelial dysfunction and lung injury were quantified by measuring angiotensin-converting enzyme release from the cell surface." @default.
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• W2076554045 date "2005-04-01" @default.
• W2076554045 modified "2023-10-16" @default.
• W2076554045 title "Propofol Attenuates Lung Endothelial Injury Induced by Ischemia-Reperfusion and Oxidative Stress" @default.
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• W2076554045 doi "https://doi.org/10.1213/01.ane.0000147707.49192.88" @default.
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