Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076555019> ?p ?o ?g. }
- W2076555019 endingPage "2196" @default.
- W2076555019 startingPage "2191" @default.
- W2076555019 abstract "Variations of protein kinase C (PKC) expression greatly influence the proliferation-to-differentiation transition (PDT) of intestinal epithelial cells and might have an important impact on intestinal tumorigenesis. We demonstrate here that the expression of PKCα in proliferating intestinal epithelial cells is repressed both in vitro and in vivo by the SOX9 transcription factor. This repression does not require DNA binding of the SOX9 high-mobility group (HMG) domain but is mediated through a new mechanism of SOX9 action requiring the central and highly conserved region of SOXE members. Because SOX9 expression is itself upregulated by Wnt-APC signaling in intestinal epithelial cells, the present study points out this transcription factor as a molecular link between the Wnt-APC pathway and PKCα. These results provide a potential explanation for the decrease of PKCα expression in colorectal cancers with constitutive activation of the Wnt-APC pathway." @default.
- W2076555019 created "2016-06-24" @default.
- W2076555019 creator A5002877692 @default.
- W2076555019 creator A5009288774 @default.
- W2076555019 creator A5011053424 @default.
- W2076555019 creator A5034666061 @default.
- W2076555019 creator A5038584483 @default.
- W2076555019 creator A5041886923 @default.
- W2076555019 creator A5052515706 @default.
- W2076555019 creator A5071321381 @default.
- W2076555019 creator A5079126152 @default.
- W2076555019 date "2009-07-01" @default.
- W2076555019 modified "2023-09-25" @default.
- W2076555019 title "A new mechanism of SOX9 action to regulate PKCα expression in the intestine epithelium" @default.
- W2076555019 cites W1492876742 @default.
- W2076555019 cites W1608008717 @default.
- W2076555019 cites W1971644781 @default.
- W2076555019 cites W1977142827 @default.
- W2076555019 cites W1987534522 @default.
- W2076555019 cites W1992660699 @default.
- W2076555019 cites W1992993098 @default.
- W2076555019 cites W1994156767 @default.
- W2076555019 cites W1997148771 @default.
- W2076555019 cites W2002554381 @default.
- W2076555019 cites W2010015925 @default.
- W2076555019 cites W2020973811 @default.
- W2076555019 cites W2021703422 @default.
- W2076555019 cites W2043765395 @default.
- W2076555019 cites W2049157134 @default.
- W2076555019 cites W2049751449 @default.
- W2076555019 cites W2057227614 @default.
- W2076555019 cites W2058860508 @default.
- W2076555019 cites W2087187482 @default.
- W2076555019 cites W2092988685 @default.
- W2076555019 cites W2094416553 @default.
- W2076555019 cites W2097890006 @default.
- W2076555019 cites W2098550169 @default.
- W2076555019 cites W2098982430 @default.
- W2076555019 cites W2104373773 @default.
- W2076555019 cites W2114198044 @default.
- W2076555019 cites W2115770951 @default.
- W2076555019 cites W2130595416 @default.
- W2076555019 cites W2139419405 @default.
- W2076555019 cites W2143697479 @default.
- W2076555019 cites W2150209245 @default.
- W2076555019 cites W2152501601 @default.
- W2076555019 doi "https://doi.org/10.1242/jcs.036483" @default.
- W2076555019 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19509063" @default.
- W2076555019 hasPublicationYear "2009" @default.
- W2076555019 type Work @default.
- W2076555019 sameAs 2076555019 @default.
- W2076555019 citedByCount "20" @default.
- W2076555019 countsByYear W20765550192012 @default.
- W2076555019 countsByYear W20765550192013 @default.
- W2076555019 countsByYear W20765550192014 @default.
- W2076555019 countsByYear W20765550192016 @default.
- W2076555019 countsByYear W20765550192017 @default.
- W2076555019 countsByYear W20765550192019 @default.
- W2076555019 countsByYear W20765550192020 @default.
- W2076555019 countsByYear W20765550192021 @default.
- W2076555019 crossrefType "journal-article" @default.
- W2076555019 hasAuthorship W2076555019A5002877692 @default.
- W2076555019 hasAuthorship W2076555019A5009288774 @default.
- W2076555019 hasAuthorship W2076555019A5011053424 @default.
- W2076555019 hasAuthorship W2076555019A5034666061 @default.
- W2076555019 hasAuthorship W2076555019A5038584483 @default.
- W2076555019 hasAuthorship W2076555019A5041886923 @default.
- W2076555019 hasAuthorship W2076555019A5052515706 @default.
- W2076555019 hasAuthorship W2076555019A5071321381 @default.
- W2076555019 hasAuthorship W2076555019A5079126152 @default.
- W2076555019 hasBestOaLocation W20765550192 @default.
- W2076555019 hasConcept C104317684 @default.
- W2076555019 hasConcept C127561419 @default.
- W2076555019 hasConcept C137620995 @default.
- W2076555019 hasConcept C150194340 @default.
- W2076555019 hasConcept C186310378 @default.
- W2076555019 hasConcept C195794163 @default.
- W2076555019 hasConcept C2778486617 @default.
- W2076555019 hasConcept C2781077229 @default.
- W2076555019 hasConcept C502942594 @default.
- W2076555019 hasConcept C529295009 @default.
- W2076555019 hasConcept C54355233 @default.
- W2076555019 hasConcept C62478195 @default.
- W2076555019 hasConcept C86339819 @default.
- W2076555019 hasConcept C86803240 @default.
- W2076555019 hasConcept C95444343 @default.
- W2076555019 hasConceptScore W2076555019C104317684 @default.
- W2076555019 hasConceptScore W2076555019C127561419 @default.
- W2076555019 hasConceptScore W2076555019C137620995 @default.
- W2076555019 hasConceptScore W2076555019C150194340 @default.
- W2076555019 hasConceptScore W2076555019C186310378 @default.
- W2076555019 hasConceptScore W2076555019C195794163 @default.
- W2076555019 hasConceptScore W2076555019C2778486617 @default.
- W2076555019 hasConceptScore W2076555019C2781077229 @default.
- W2076555019 hasConceptScore W2076555019C502942594 @default.
- W2076555019 hasConceptScore W2076555019C529295009 @default.
- W2076555019 hasConceptScore W2076555019C54355233 @default.
- W2076555019 hasConceptScore W2076555019C62478195 @default.