FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076558034> ?p ?o ?g. }

• W2076558034 endingPage "1403" @default.
• W2076558034 startingPage "1396" @default.
• W2076558034 abstract "Abstract Dendritic cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN) C-type lectin is almost exclusively expressed at the cell surface of DC. In addition to its normal function facilitating contact of DC with T cells, DC-SIGN has been shown to bind a variety of pathogens, including Mycobacterium bovis, and HIV-1 envelope protein gp120. In this study, we identified the bovine ortholog of the human DC-SIGN gene within the bovine genome, which exists as a single copy. PCR amplified a product, showing a 100% match with the predicted sequences as well as a sequence predicted to be similar to that of SIGNR7. Furthermore, a protein with the same molecular weight as human DC-SIGN was detected by Western blot in cell lysate derived from bovine DC. To characterize this molecule functionally, the uptake of FITC-labeled OVA and FITC-labeled gp120 (FITC-gp120) by bovine and human DC was assessed. FITC-gp120 was shown to bind to bovine DC in a time- and temperature-dependent manner. Binding was blocked by a polyclonal anti-DC-SIGN antibody but not by a control antibody. Furthermore, blocking of this molecule also reduced the binding of M. bovis bacillus Calmette-Guerin expressing GFP. Confocal microscopy showed that DC-SIGN was expressed on the surface of bovine DC. Subsequent pulse-chase studies revealed that FITC-gp120 was internalized by bovine monocyte-derived DC as early as 10 min. Thus, there is evidence of a DC-SIGN-like molecule expressed specifically by bovine DC. This molecule may play an important role in the infection of bovine (DC) cells with M. bovis." @default.
• W2076558034 created "2016-06-24" @default.
• W2076558034 creator A5005165452 @default.
• W2076558034 creator A5012367717 @default.
• W2076558034 creator A5018058307 @default.
• W2076558034 creator A5018778541 @default.
• W2076558034 creator A5025713181 @default.
• W2076558034 creator A5037240826 @default.
• W2076558034 creator A5061861242 @default.
• W2076558034 creator A5070697613 @default.
• W2076558034 date "2008-03-03" @default.
• W2076558034 modified "2023-09-26" @default.
• W2076558034 title "Identification and functional characterization of a bovine orthologue to DC-SIGN" @default.
• W2076558034 cites W1661544713 @default.
• W2076558034 cites W1971684682 @default.
• W2076558034 cites W1978775471 @default.
• W2076558034 cites W1981350458 @default.
• W2076558034 cites W1988554751 @default.
• W2076558034 cites W1990283625 @default.
• W2076558034 cites W1990693013 @default.
• W2076558034 cites W2004998426 @default.
• W2076558034 cites W2008232522 @default.
• W2076558034 cites W2014358201 @default.
• W2076558034 cites W2016475905 @default.
• W2076558034 cites W2028364415 @default.
• W2076558034 cites W2028787451 @default.
• W2076558034 cites W2042016124 @default.
• W2076558034 cites W2052588752 @default.
• W2076558034 cites W2062200101 @default.
• W2076558034 cites W2062561488 @default.
• W2076558034 cites W2086155380 @default.
• W2076558034 cites W2091739027 @default.
• W2076558034 cites W2097382368 @default.
• W2076558034 cites W2101994976 @default.
• W2076558034 cites W2105952229 @default.
• W2076558034 cites W2109204917 @default.
• W2076558034 cites W2109368536 @default.
• W2076558034 cites W2113280649 @default.
• W2076558034 cites W2118127427 @default.
• W2076558034 cites W2118230200 @default.
• W2076558034 cites W2118390380 @default.
• W2076558034 cites W2124285343 @default.
• W2076558034 cites W2128223406 @default.
• W2076558034 cites W2129442719 @default.
• W2076558034 cites W2145508988 @default.
• W2076558034 cites W2148047088 @default.
• W2076558034 cites W2156643487 @default.
• W2076558034 cites W2163570329 @default.
• W2076558034 cites W2167689734 @default.
• W2076558034 cites W2168523433 @default.
• W2076558034 cites W2177327503 @default.
• W2076558034 cites W90568390 @default.
• W2076558034 doi "https://doi.org/10.1189/jlb.0807523" @default.
• W2076558034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18319290" @default.
• W2076558034 hasPublicationYear "2008" @default.
• W2076558034 type Work @default.
• W2076558034 sameAs 2076558034 @default.
• W2076558034 citedByCount "22" @default.
• W2076558034 countsByYear W20765580342012 @default.
• W2076558034 countsByYear W20765580342014 @default.
• W2076558034 countsByYear W20765580342015 @default.
• W2076558034 countsByYear W20765580342016 @default.
• W2076558034 countsByYear W20765580342020 @default.
• W2076558034 crossrefType "journal-article" @default.
• W2076558034 hasAuthorship W2076558034A5005165452 @default.
• W2076558034 hasAuthorship W2076558034A5012367717 @default.
• W2076558034 hasAuthorship W2076558034A5018058307 @default.
• W2076558034 hasAuthorship W2076558034A5018778541 @default.
• W2076558034 hasAuthorship W2076558034A5025713181 @default.
• W2076558034 hasAuthorship W2076558034A5037240826 @default.
• W2076558034 hasAuthorship W2076558034A5061861242 @default.
• W2076558034 hasAuthorship W2076558034A5070697613 @default.
• W2076558034 hasBestOaLocation W20765580341 @default.
• W2076558034 hasConcept C106257327 @default.
• W2076558034 hasConcept C147483822 @default.
• W2076558034 hasConcept C153911025 @default.
• W2076558034 hasConcept C159654299 @default.
• W2076558034 hasConcept C193976658 @default.
• W2076558034 hasConcept C2778170410 @default.
• W2076558034 hasConcept C2780758401 @default.
• W2076558034 hasConcept C54355233 @default.
• W2076558034 hasConcept C55493867 @default.
• W2076558034 hasConcept C86803240 @default.
• W2076558034 hasConcept C86807702 @default.
• W2076558034 hasConcept C956191 @default.
• W2076558034 hasConceptScore W2076558034C106257327 @default.
• W2076558034 hasConceptScore W2076558034C147483822 @default.
• W2076558034 hasConceptScore W2076558034C153911025 @default.
• W2076558034 hasConceptScore W2076558034C159654299 @default.
• W2076558034 hasConceptScore W2076558034C193976658 @default.
• W2076558034 hasConceptScore W2076558034C2778170410 @default.
• W2076558034 hasConceptScore W2076558034C2780758401 @default.
• W2076558034 hasConceptScore W2076558034C54355233 @default.
• W2076558034 hasConceptScore W2076558034C55493867 @default.
• W2076558034 hasConceptScore W2076558034C86803240 @default.
• W2076558034 hasConceptScore W2076558034C86807702 @default.
• W2076558034 hasConceptScore W2076558034C956191 @default.
• W2076558034 hasFunder F4320320325 @default.

• next