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- W2076559523 abstract "It is well known that G-rich phosphorothioate oligonucleotides (G-rich PS) bind to the V3 loop of HIV-1 gp120 and inhibit HIV-1 infection. In this study, we investigated the inhibitory mechanism of a new type of G-rich PS (PS-G3T4G3) on the replication cycle of HIV-1. PS-G3T4G3 inhibits both cell to cell and cell free infections. Binding and entry assays revealed that the inhibitory step of PS-G3T4G3 occurs at the early stage of HIV-1 infection. V3 loop-specific mAb test showed that PS-G3T4G3 binds to the V3 loop and prevents its interaction with chemokine receptors. These results suggest that PS-G3T4G3 may be a novel candidate for an HIV-1 inhibitor." @default.
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- W2076559523 date "1999-11-01" @default.
- W2076559523 modified "2023-09-27" @default.
- W2076559523 title "Phosphorothioate G3T4G3 motifs inhibits the early stage of HIV-1 infection" @default.
- W2076559523 doi "https://doi.org/10.1093/nass/42.1.227" @default.
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