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- W2076559543 abstract "Werner syndrome (WS) is an excellent model system for the study of human aging. WRN, a nuclear protein mutated in WS, plays multiple roles in DNA metabolism. Our understanding about the metabolic regulation and function of this RecQ helicase has advanced greatly during the past decade, largely due to the availability of purified WRN protein, WRN knockdown cells, and WRN knockout mice. Recent biochemical and genetic studies indicate that WRN plays significant roles in DNA replication, DNA repair, and telomere maintenance. Interestingly, many WRN functions require handling of DNA ends during S-phase, and evidence suggests that WRN plays both upstream and downstream roles in the response to DNA damage. Future research should focus on the mechanism(s) of WRN in the regulation of the various DNA metabolism pathways and development of therapeutic approaches to treat premature aging syndromes such as WS." @default.
- W2076559543 created "2016-06-24" @default.
- W2076559543 creator A5068778669 @default.
- W2076559543 creator A5074486459 @default.
- W2076559543 creator A5089917586 @default.
- W2076559543 date "2007-09-01" @default.
- W2076559543 modified "2023-10-18" @default.
- W2076559543 title "Werner syndrome protein: Functions in the response to DNA damage and replication stress in S-phase" @default.
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- W2076559543 doi "https://doi.org/10.1016/j.exger.2007.04.011" @default.
- W2076559543 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17587522" @default.
- W2076559543 hasPublicationYear "2007" @default.
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