FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076565732> ?p ?o ?g. }

• W2076565732 endingPage "35" @default.
• W2076565732 startingPage "23" @default.
• W2076565732 abstract "1. Although the control of steroidogenic activity of the Leydig cell by the peptides luteinizing hormone (LH) and human chorionic gonadotrophin (hCG) is clearly mediated by cAMP, the extent to which Ca2+ controls the Leydig cell function is less well defined. In the present study, the whole-cell configuration of the patch-clamp technique was used to investigate the modulation of potassium conductances by calcium and hCG, in the Leydig cells from mature rat testis. 2. In symmetrical glutamate solutions, depolarizations elicited outwardly rectifying currents, which were mainly carried by potassium and were blocked by tetraethylammonium and 4-aminopyridine. For values of [Ca2+]i below 10(-8) M, transient currents of low amplitudes, insensitive to charybdotoxin (CTX) and iberiotoxin (IBTX), were activated above -40 mV. For [Ca2+]i values of 10(-7) M and above, noisy currents with slow activation kinetics were activated above 0 mV. These currents were sustained and were sensitive to CTX and IBTX. 3. Both current types were modulated by intracellular calcium. Ionomycin and a [Ca2+]i elevation in the range from 10(-9) to 10(-7) M, both inhibited the CTX-insensitive currents, whereas a rise in the calcium concentration above 10(-7) M increased the amplitude and shifted the threshold of activation of the CTX-sensitive currents to less positive levels. 4. hCG (1-50 i.u. ml-1), in conditions where the chloride currents were strongly inhibited by 4-acetamido-4'-isothiocyanatostilbene-2,2'-disulphonic acid (SITS), induced a partial inhibition of the CTX-insensitive currents but was unable to increase the CTX-sensitive currents. 5. No voltage-sensitive calcium current was recorded in control or hCG-stimulated cells. 6. The results indicate that hCG inhibits one kind of Ca(2+)-modulated channel, perhaps as a result of a moderate [Ca2+]i rise, but is unable to increase the intracellular Ca2+ concentration to the range in which large conductance Ca(2+)-dependent channels are activated." @default.
• W2076565732 created "2016-06-24" @default.
• W2076565732 creator A5050434892 @default.
• W2076565732 creator A5061028978 @default.
• W2076565732 creator A5091503484 @default.
• W2076565732 date "1996-08-15" @default.
• W2076565732 modified "2023-09-25" @default.
• W2076565732 title "Modulation of K+ conductances by Ca2+ and human chorionic gonadotrophin in Leydig cells from mature rat testis." @default.
• W2076565732 cites W1496902535 @default.
• W2076565732 cites W1503203225 @default.
• W2076565732 cites W1555733423 @default.
• W2076565732 cites W1579743167 @default.
• W2076565732 cites W1593025965 @default.
• W2076565732 cites W1861400014 @default.
• W2076565732 cites W1965188573 @default.
• W2076565732 cites W1966038203 @default.
• W2076565732 cites W1969521519 @default.
• W2076565732 cites W1974558586 @default.
• W2076565732 cites W1976721125 @default.
• W2076565732 cites W1977063611 @default.
• W2076565732 cites W1989572975 @default.
• W2076565732 cites W1989580086 @default.
• W2076565732 cites W2027964002 @default.
• W2076565732 cites W2037763262 @default.
• W2076565732 cites W2040564344 @default.
• W2076565732 cites W2040877330 @default.
• W2076565732 cites W2042276783 @default.
• W2076565732 cites W2070015190 @default.
• W2076565732 cites W2079453878 @default.
• W2076565732 cites W2082304034 @default.
• W2076565732 cites W2131730319 @default.
• W2076565732 cites W2137760362 @default.
• W2076565732 cites W2138761145 @default.
• W2076565732 cites W2146152598 @default.
• W2076565732 cites W2299511304 @default.
• W2076565732 cites W3169054686 @default.
• W2076565732 doi "https://doi.org/10.1113/jphysiol.1996.sp021571" @default.
• W2076565732 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1160722" @default.
• W2076565732 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8866349" @default.
• W2076565732 hasPublicationYear "1996" @default.
• W2076565732 type Work @default.
• W2076565732 sameAs 2076565732 @default.
• W2076565732 citedByCount "6" @default.
• W2076565732 countsByYear W20765657322013 @default.
• W2076565732 crossrefType "journal-article" @default.
• W2076565732 hasAuthorship W2076565732A5050434892 @default.
• W2076565732 hasAuthorship W2076565732A5061028978 @default.
• W2076565732 hasAuthorship W2076565732A5091503484 @default.
• W2076565732 hasBestOaLocation W20765657321 @default.
• W2076565732 hasConcept C12554922 @default.
• W2076565732 hasConcept C126322002 @default.
• W2076565732 hasConcept C134018914 @default.
• W2076565732 hasConcept C147944092 @default.
• W2076565732 hasConcept C178790620 @default.
• W2076565732 hasConcept C185263204 @default.
• W2076565732 hasConcept C185592680 @default.
• W2076565732 hasConcept C2777736315 @default.
• W2076565732 hasConcept C2778575703 @default.
• W2076565732 hasConcept C2779411790 @default.
• W2076565732 hasConcept C2780419564 @default.
• W2076565732 hasConcept C2780918503 @default.
• W2076565732 hasConcept C2781295685 @default.
• W2076565732 hasConcept C517785266 @default.
• W2076565732 hasConcept C519063684 @default.
• W2076565732 hasConcept C55493867 @default.
• W2076565732 hasConcept C71315377 @default.
• W2076565732 hasConcept C71924100 @default.
• W2076565732 hasConcept C79879829 @default.
• W2076565732 hasConcept C83743174 @default.
• W2076565732 hasConcept C86803240 @default.
• W2076565732 hasConceptScore W2076565732C12554922 @default.
• W2076565732 hasConceptScore W2076565732C126322002 @default.
• W2076565732 hasConceptScore W2076565732C134018914 @default.
• W2076565732 hasConceptScore W2076565732C147944092 @default.
• W2076565732 hasConceptScore W2076565732C178790620 @default.
• W2076565732 hasConceptScore W2076565732C185263204 @default.
• W2076565732 hasConceptScore W2076565732C185592680 @default.
• W2076565732 hasConceptScore W2076565732C2777736315 @default.
• W2076565732 hasConceptScore W2076565732C2778575703 @default.
• W2076565732 hasConceptScore W2076565732C2779411790 @default.
• W2076565732 hasConceptScore W2076565732C2780419564 @default.
• W2076565732 hasConceptScore W2076565732C2780918503 @default.
• W2076565732 hasConceptScore W2076565732C2781295685 @default.
• W2076565732 hasConceptScore W2076565732C517785266 @default.
• W2076565732 hasConceptScore W2076565732C519063684 @default.
• W2076565732 hasConceptScore W2076565732C55493867 @default.
• W2076565732 hasConceptScore W2076565732C71315377 @default.
• W2076565732 hasConceptScore W2076565732C71924100 @default.
• W2076565732 hasConceptScore W2076565732C79879829 @default.
• W2076565732 hasConceptScore W2076565732C83743174 @default.
• W2076565732 hasConceptScore W2076565732C86803240 @default.
• W2076565732 hasIssue "1" @default.
• W2076565732 hasLocation W20765657321 @default.
• W2076565732 hasLocation W20765657322 @default.
• W2076565732 hasLocation W20765657323 @default.
• W2076565732 hasOpenAccess W2076565732 @default.
• W2076565732 hasPrimaryLocation W20765657321 @default.
• W2076565732 hasRelatedWork W2001072936 @default.

• next