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• W2076566094 abstract "DNA damage was apparently introduced selectively in the parts of DNA localized close to the nuclear membrane of human NHIK 3025 cells. This was obtained by illumination of the cells in the presence of a hydrophobic photosensitizer, Photofrin II, which was located in membrane structures but not in the nucleus. Photofrin II sensitizes DNA to light mainly via singlet oxygen, which diffuses about 0.1 μm in its intracellular lifetime. By measuring DNA unwinding in alkali after illumination or X-irradiation of cells, the distribution of the number of DNA bases between two adjacent, photodamaged DNA sites was estimated. The average length of these DNA fragments was found to be 155 kilobases (kb)." @default.
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• W2076566094 date "1990-05-01" @default.
• W2076566094 modified "2023-09-27" @default.
• W2076566094 title "The lengths of DNA fragments light-induced in the presence of a photosensitizer localized at the nuclear membrane of human cells" @default.
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• W2076566094 doi "https://doi.org/10.1016/0167-4781(90)90081-c" @default.
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