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- W2076570147 abstract "To determine dementia stages, “The Clinical Dementia Rating scale” proposed by J.C. Morris is widely used in the world clinical practice. Alzheimer's disease (AD) development is accompanied by temporal and fronto-parietal brain regions atrophy increase which in turn causes dementia development. To determine AD dementia stages, we propose to complement the scale by objective CT and MRI morphological data showing atrophy severity in accordance with the clinical stage. Since fronto-parietal regions allocation is difficult, we calculated temporal regions atrophy, focusing on bone formations. The resulting scale was named The Tomography Dementia Rating scale (TDR). The research included 108 patients: 49 aged 34-80 with AD various stages - Test Group; 59 aged 28-78 with various kinds of brain lesions with dementia but without AD (moderate and severe vascular dementia, Parkinson's atherosclerosis, Binswanger's disease, Parkinson's disease) - Control Group. All patients underwent MRI, CT with subsequent temporal lobes atrophy degree calculation, brain scintigraphy (SG), rheoencephalography (REG), cerebral angiography (MUGA). Preclinical AD stage (those with high probability of AD inheritance, growing memory disorders, immediate relatives suffering from AD, without dementia or cognitive impairment) - TDR-0: temporal lobes atrophy with 4-8% tissue mass decrease. Early AD stage - mild dementia - TDR-1: temporal lobes atrophy with 9-18% tissue mass decrease (corresponds to CDR-1). Average AD stage - mild dementia - TDR-2: temporal lobes atrophy with 19-32% tissue mass decrease (corresponds to CDR-2). Late AD stage - severe dementia - TDR-3: temporal lobes atrophy with 33-62% tissue mass decrease (corresponds to CDR-3). These atrophic changes are not observed among patients with other cerebral lesions. Morphologically determined characteristics of Alzheimer's disease stages obtained by means of the tomography dementia rating scale based on the degree of brain temporal lobes atrophy." @default.
- W2076570147 created "2016-06-24" @default.
- W2076570147 creator A5084463740 @default.
- W2076570147 date "2012-07-01" @default.
- W2076570147 modified "2023-09-27" @default.
- W2076570147 title "P2-220: The tomography dementia rating scale: Morphologically determined scale of Alzheimer's disease stages" @default.
- W2076570147 doi "https://doi.org/10.1016/j.jalz.2012.05.927" @default.
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