Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076571657> ?p ?o ?g. }
- W2076571657 endingPage "895" @default.
- W2076571657 startingPage "890" @default.
- W2076571657 abstract "The aim of this study was to investigate whether C1q/TNF-related protein 9 (CTRP9) could stabilize the mature plaques by targeting macrophages in the apolipoprotein E knockout (ApoE KO) mice model. In vivo, the mice were subjected to high-fat diet and constrictive collars on the right carotid artery for eight weeks, a lentiviral vectors expressing CTRP9 (LV-CTRP9) or green fluorescence protein (LV-eGFP) as a control was intravenously injected into ApoE KO mice. Delivery of LV-CTRP9 resulted in low contents of macrophages and lipids, and high contents of collagen and vascular smooth muscle cells in the carotid mature plaques. In addition, CTRP9 also decreased pro-inflammatory cytokines in mature plaques. In vitro, RAW264.7 macrophages were pretreated with or without LV-CTRP9 transfection, and then stimulated with oxLDL (50 μg/mL). We found that the expression levels of tumor necrosis factor-α (TNF-α) and monocyte chemoattractant protein 1 (MCP-1) in the LV-CTRP9 group were significantly lower than those in the LV-eGFP group after exposure to oxLDL. The present data indicate that CTRP9 overexpression enhances the plaque stability in ApoE KO mice by reducing pro-inflammatory cytokines in macrophages. Our study suggests that the therapeutic approaches to enhance CTRP9 production could be valuable for plaque stabilization." @default.
- W2076571657 created "2016-06-24" @default.
- W2076571657 creator A5006549974 @default.
- W2076571657 creator A5006630986 @default.
- W2076571657 creator A5012031906 @default.
- W2076571657 creator A5023819550 @default.
- W2076571657 creator A5023874610 @default.
- W2076571657 creator A5025034745 @default.
- W2076571657 creator A5029360035 @default.
- W2076571657 creator A5057458570 @default.
- W2076571657 creator A5059636217 @default.
- W2076571657 creator A5061396145 @default.
- W2076571657 creator A5071490870 @default.
- W2076571657 date "2015-03-01" @default.
- W2076571657 modified "2023-09-25" @default.
- W2076571657 title "CTRP9 enhances carotid plaque stability by reducing pro-inflammatory cytokines in macrophages" @default.
- W2076571657 cites W1965112234 @default.
- W2076571657 cites W1968876618 @default.
- W2076571657 cites W1974762968 @default.
- W2076571657 cites W1976578586 @default.
- W2076571657 cites W1990932830 @default.
- W2076571657 cites W2000265203 @default.
- W2076571657 cites W2000949542 @default.
- W2076571657 cites W2005505978 @default.
- W2076571657 cites W2020780927 @default.
- W2076571657 cites W2021873664 @default.
- W2076571657 cites W2023797875 @default.
- W2076571657 cites W2029215594 @default.
- W2076571657 cites W2029470815 @default.
- W2076571657 cites W2030611470 @default.
- W2076571657 cites W2035483254 @default.
- W2076571657 cites W2054322029 @default.
- W2076571657 cites W2054753294 @default.
- W2076571657 cites W2057527114 @default.
- W2076571657 cites W2064057777 @default.
- W2076571657 cites W2083169533 @default.
- W2076571657 cites W2086222836 @default.
- W2076571657 cites W2095949331 @default.
- W2076571657 cites W2112103567 @default.
- W2076571657 cites W2113934014 @default.
- W2076571657 cites W2122394887 @default.
- W2076571657 cites W2147181044 @default.
- W2076571657 cites W2159087408 @default.
- W2076571657 cites W2159284697 @default.
- W2076571657 cites W2163160776 @default.
- W2076571657 doi "https://doi.org/10.1016/j.bbrc.2015.02.054" @default.
- W2076571657 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25701788" @default.
- W2076571657 hasPublicationYear "2015" @default.
- W2076571657 type Work @default.
- W2076571657 sameAs 2076571657 @default.
- W2076571657 citedByCount "46" @default.
- W2076571657 countsByYear W20765716572016 @default.
- W2076571657 countsByYear W20765716572017 @default.
- W2076571657 countsByYear W20765716572018 @default.
- W2076571657 countsByYear W20765716572019 @default.
- W2076571657 countsByYear W20765716572020 @default.
- W2076571657 countsByYear W20765716572021 @default.
- W2076571657 countsByYear W20765716572022 @default.
- W2076571657 countsByYear W20765716572023 @default.
- W2076571657 crossrefType "journal-article" @default.
- W2076571657 hasAuthorship W2076571657A5006549974 @default.
- W2076571657 hasAuthorship W2076571657A5006630986 @default.
- W2076571657 hasAuthorship W2076571657A5012031906 @default.
- W2076571657 hasAuthorship W2076571657A5023819550 @default.
- W2076571657 hasAuthorship W2076571657A5023874610 @default.
- W2076571657 hasAuthorship W2076571657A5025034745 @default.
- W2076571657 hasAuthorship W2076571657A5029360035 @default.
- W2076571657 hasAuthorship W2076571657A5057458570 @default.
- W2076571657 hasAuthorship W2076571657A5059636217 @default.
- W2076571657 hasAuthorship W2076571657A5061396145 @default.
- W2076571657 hasAuthorship W2076571657A5071490870 @default.
- W2076571657 hasConcept C126322002 @default.
- W2076571657 hasConcept C134018914 @default.
- W2076571657 hasConcept C150903083 @default.
- W2076571657 hasConcept C164027704 @default.
- W2076571657 hasConcept C17991360 @default.
- W2076571657 hasConcept C185592680 @default.
- W2076571657 hasConcept C202751555 @default.
- W2076571657 hasConcept C207001950 @default.
- W2076571657 hasConcept C2776914184 @default.
- W2076571657 hasConcept C2779134260 @default.
- W2076571657 hasConcept C2779244956 @default.
- W2076571657 hasConcept C2781184567 @default.
- W2076571657 hasConcept C55493867 @default.
- W2076571657 hasConcept C57089818 @default.
- W2076571657 hasConcept C71924100 @default.
- W2076571657 hasConcept C86803240 @default.
- W2076571657 hasConceptScore W2076571657C126322002 @default.
- W2076571657 hasConceptScore W2076571657C134018914 @default.
- W2076571657 hasConceptScore W2076571657C150903083 @default.
- W2076571657 hasConceptScore W2076571657C164027704 @default.
- W2076571657 hasConceptScore W2076571657C17991360 @default.
- W2076571657 hasConceptScore W2076571657C185592680 @default.
- W2076571657 hasConceptScore W2076571657C202751555 @default.
- W2076571657 hasConceptScore W2076571657C207001950 @default.
- W2076571657 hasConceptScore W2076571657C2776914184 @default.
- W2076571657 hasConceptScore W2076571657C2779134260 @default.
- W2076571657 hasConceptScore W2076571657C2779244956 @default.