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• W2076571832 abstract "Experiments with cultured cells showed that most cellular stress resistance components are specialized for certain types of damage. For example, superoxide dismutase protects from oxidative damage; DNA repair enzymes guard against mutagens and other DNA-damaging agents. On the other hand, the major inducible heat shock protein Hsp72 protects cells from a large variety of stresses and thus represents a generalized repair/stress resistance component. Hsp72 not only refolds damaged proteins but also interferes with programmed cell death signaling pathways, thus providing cells with time to repair the damage, hence its universality as a stress protector. In the present study we demonstrate the occurrence in murine and human ascites fluids (AF) of a natural nontoxic extracellular factor (ascites Hsp72-inducing factor, AHIF) capable of activating Hsp72 expression in different types of cells via a pathway distinct from the heat shock response pathway. AHIF is unique in that it is the first physiological factor capable of inducing synthesis of Hsp72 not only in young cells but, remarkably, also in aged human cells that largely have lost the ability to express Hsp72 in response to stresses, a manifestation at the cellular level of a progressive impairment in the ability to adapt to environmental changes which characterizes aging. Pretreatment of aged human cells with AF triggers Hsp72 expression at levels seen in young stressed cells and protects cells from a variety of otherwise lethal stressful treatments such as heat shock, TNF, UV irradiation, etoposide, and menadione. Activation of Hsp72 expression is essential for antiapoptotic action of AHIF because specific inhibition of Hsp72 expression by antisense RNA abolishes the cytoprotective effect of AF. In view of an important link between stress resistance and longevity in different organisms, the abilities of AHIF make it a unique candidate for the role of a systemic regulator of the aging process. While a cell-autonomous stress response diminishes with aging, aged cells retain the ability to respond to an extracellular factor which induces the expression of Hsp72. This finding opens up exciting possibilities for using AF factor to restore stress resistance to old cells and organisms and the possibility of interfering with the aging process. The ability to induce stress resistance in young cells and to restore it in aged cells could serve as a basis for developing effective antiapoptotic therapies." @default.
• W2076571832 created "2016-06-24" @default.
• W2076571832 creator A5044183739 @default.
• W2076571832 creator A5052863915 @default.
• W2076571832 date "1999-12-01" @default.
• W2076571832 modified "2023-10-16" @default.
• W2076571832 title "A Natural Extracellular Factor That Induces Hsp72, Inhibits Apoptosis, and Restores Stress Resistance in Aged Human Cells" @default.
• W2076571832 cites W1489733307 @default.
• W2076571832 cites W1522402713 @default.
• W2076571832 cites W1535702947 @default.
• W2076571832 cites W1537179709 @default.
• W2076571832 cites W1600394682 @default.
• W2076571832 cites W1608870486 @default.
• W2076571832 cites W1621906674 @default.
• W2076571832 cites W1622572912 @default.
• W2076571832 cites W1724563161 @default.
• W2076571832 cites W1769448430 @default.
• W2076571832 cites W1809054409 @default.
• W2076571832 cites W1938310987 @default.
• W2076571832 cites W1938564032 @default.
• W2076571832 cites W1964564693 @default.
• W2076571832 cites W1969158591 @default.
• W2076571832 cites W1970265839 @default.
• W2076571832 cites W1974878663 @default.
• W2076571832 cites W1974886740 @default.
• W2076571832 cites W1976385326 @default.
• W2076571832 cites W1976619017 @default.
• W2076571832 cites W1985263804 @default.
• W2076571832 cites W1990315727 @default.
• W2076571832 cites W1995865008 @default.
• W2076571832 cites W1997171926 @default.
• W2076571832 cites W2005029264 @default.
• W2076571832 cites W2005289306 @default.
• W2076571832 cites W2007501972 @default.
• W2076571832 cites W2007768216 @default.
• W2076571832 cites W2013742279 @default.
• W2076571832 cites W2017792000 @default.
• W2076571832 cites W2023878839 @default.
• W2076571832 cites W2030130178 @default.
• W2076571832 cites W2030352844 @default.
• W2076571832 cites W2030802741 @default.
• W2076571832 cites W2031823980 @default.
• W2076571832 cites W2032449873 @default.
• W2076571832 cites W2032739238 @default.
• W2076571832 cites W2034002417 @default.
• W2076571832 cites W2046351190 @default.
• W2076571832 cites W2046989794 @default.
• W2076571832 cites W2052083260 @default.
• W2076571832 cites W2054473882 @default.
• W2076571832 cites W2061738083 @default.
• W2076571832 cites W2062048451 @default.
• W2076571832 cites W2064858516 @default.
• W2076571832 cites W2066378745 @default.
• W2076571832 cites W2068050620 @default.
• W2076571832 cites W2074169536 @default.
• W2076571832 cites W2075026875 @default.
• W2076571832 cites W2076862161 @default.
• W2076571832 cites W2082468639 @default.
• W2076571832 cites W2084255798 @default.
• W2076571832 cites W2085509769 @default.
• W2076571832 cites W2093935763 @default.
• W2076571832 cites W2097133415 @default.
• W2076571832 cites W2105000276 @default.
• W2076571832 cites W2109695451 @default.
• W2076571832 cites W2114360920 @default.
• W2076571832 cites W2121121789 @default.
• W2076571832 cites W2123446343 @default.
• W2076571832 cites W2123551177 @default.
• W2076571832 cites W2145387039 @default.
• W2076571832 cites W2151160060 @default.
• W2076571832 cites W2161758212 @default.
• W2076571832 cites W2162754641 @default.
• W2076571832 cites W2167567258 @default.
• W2076571832 cites W2168857422 @default.
• W2076571832 cites W2326945343 @default.
• W2076571832 cites W3143608703 @default.
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• W2076571832 cites W4241718232 @default.
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• W2076571832 doi "https://doi.org/10.1006/excr.1999.4682" @default.
• W2076571832 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10585271" @default.
• W2076571832 hasPublicationYear "1999" @default.
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