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- W2076576012 abstract "The chemistry and the pharmacology of the nitrogen “mustards” are briefly summarised, and the importance of azo compounds in cancer research is indicated. The concept of “latent activity” is introduced, and special attention is devoted to the p-phenylazo derivatives of NN-bischloroethylaniline as examples of such compounds used in the chemotherapy of cancer.The literature concerning the rates of reduction of azo compounds is briefly reviewed. The rates of reduction of some derivatives of 4–NN-bis-2″-chloroethylamino-azobenzene with stannous chloride, hydrazine, and the xanthine—xanthine oxidase system are discussed in relation to the electronic character of ring substituents; attention is drawn to certain anomalous “ortho” effects. The rates of reduction are discussed also in relation to the observed tumour-growth-inhibiting properties of the compounds." @default.
- W2076576012 created "2016-06-24" @default.
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- W2076576012 date "2008-10-22" @default.
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- W2076576012 title "Relative Rates of Reduction of a Series of Azo Compounds" @default.
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- W2076576012 doi "https://doi.org/10.1111/j.1478-4408.1959.tb02328.x" @default.
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